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• W2019947947 abstract "The most popular causal hypothesis for idiopathic dilated cardiomyopathy (IDC) is an autoimmune process initiated by an environmental trigger. 1 Giles T.D Report of the WHO/ISFC task force on the definition and classification of cardiomyopathies. Circulation. 1996; 93: 841-842 Crossref PubMed Scopus (2739) Google Scholar This autoimmune theory arose from observations of increased frequency of human leukocyte antigen (HLA)-DR4 and the presence of circulating cardiac autoantibodies in some patients with IDC. 2 Anderson J.L Carlquist J.F Lutz J.R DeWitt C.W Hammond E.H HLA A, B and DR typing in idiopathic dilated cardiomyopathy a search for immune response factors. Am J Cardiol. 1984; 53: 1326-1330 Abstract Full Text PDF PubMed Scopus (65) Google Scholar , 3 Caforio A.L.P Bonifacio E Stewart J.T Neglia D Parodi O Bottazzo G.F McKenna W.J Novel organ-specific autoantibodies in dilated cardiomyopathy. J Am Coll Cardiol. 1990; 15: 1527-1534 Abstract Full Text PDF PubMed Scopus (154) Google Scholar , 4 Caforio A.L.P Keeling P.J Zachara E Mestroni L Camerini F Mann J.M McKenna W.J Evidence from familial studies for autoimmunity in dilated cardiomyopathy. Lancet. 1994; 344: 773-777 Abstract PubMed Scopus (132) Google Scholar , 5 Michels V.V Moll P.P Rodeheffer R.J Miller F.A Tajik A.J Burnett J.C Driscoll D.J Thibodeau S.N Ansari A.A Herskowitz A Circulating heart autoantibodies in familial as compared with nonfamilial idiopathic dilated cardiomyopathy. Mayo Clin Proc. 1994; 69: 24-27 Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar The increased frequency of the DR4 haplotype appears restricted to familial IDC, suggesting that these patients inherit an autoimmune predisposition to the disease. 6 McKenna C.J Codd M.B McCann H.A Sugrue D.D Idiopathic dilated cardiomyopathy familial prevalence and HLA distribution. Heart. 1997; 77: 549-552 Crossref PubMed Scopus (51) Google Scholar Prospective studies in which relatives of patients with IDC were screened by echocardiography have consistently demonstrated a familial prevalence of 25%. 6 McKenna C.J Codd M.B McCann H.A Sugrue D.D Idiopathic dilated cardiomyopathy familial prevalence and HLA distribution. Heart. 1997; 77: 549-552 Crossref PubMed Scopus (51) Google Scholar , 7 Michels V.V Moll P.P Miller F.A Tajik A.J Chu J.S Driscoll D.J Burnett J.C Rodeheffer R.J Chesboro J.H Tazelaar H.D The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. N Engl J Med. 1992; 326: 77-82 Crossref PubMed Scopus (560) Google Scholar , 8 Keeling P.J Gang Y Smith G Seo H Bent S.E Murday V Caforio A.L McKenna W.J Familial dilated cardiomyopathy in the United Kingdom. Br Heart J. 1995; 73: 417-421 Crossref PubMed Scopus (151) Google Scholar Echocardiographic screening of asymptomatic relatives of patients with IDC thus identifies a subset with left ventricular (LV) enlargement who are assumed to have early familial IDC. We report the results of myocardial biopsy specimens obtained during diagnostic workup in 5 such asymptomatic relatives." @default.
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• W2019947947 date "1999-01-01" @default.
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• W2019947947 title "Histopathologic changes in asymptomatic relatives of patients with idiopathic dilated cardiomyopathy" @default.
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• W2019947947 doi "https://doi.org/10.1016/s0002-9149(98)00840-6" @default.
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