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• W2019948763 abstract "The present study investigated the mechanism of mouse pancreatic acinar cell apoptosis induced by H 2 S in an in vitro system, using isolated pancreatic acini. Treatment of pancreatic acini with 10 μM NaHS (a donor of H 2 S) for 3 h caused phosphatidylserine externalization as shown by annexin V binding, an indicator of early stages of apoptosis. This treatment also resulted in the activation of the caspase cascade and major changes at the mitochondrial level. Caspase-3, -8, and -9 activities were stimulated by H 2 S treatment. Treatment with inhibitors of caspase-3, -8, and -9 significantly inhibited H 2 S-induced phosphatidylserine externalization as shown by reduced annexin V staining. The mitochondrial membrane potential was collapsed in H 2 S-treated acini as evidenced by fluorescence microscopy and quantitative analysis. Furthermore, the treatment of acini with H 2 S caused the release of cytochrome c by the mitochondria. To investigate the mechanism underlying pancreatic acinar cell apoptosis, we also characterized the protein expression of a range of molecules that are each known to influence the apoptotic pathway. Among proapoptotic proteins, Bax expression was activated in H 2 S-treated cells but not Bid, and the antiapoptotic proteins Bcl-X L and Bcl-2 did not show any activation in pancreatic acinar cell apoptosis. The death effector domain-containing protein Flip is downregulated in H 2 S-treated acini. These results demonstrate the induction of pancreatic acinar cell apoptosis in vitro by H 2 S and the involvement of both mitochondrial and death receptor pathways in the process of apoptosis." @default.
• W2019948763 created "2016-06-24" @default.
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• W2019948763 date "2006-09-01" @default.
• W2019948763 modified "2023-10-17" @default.
• W2019948763 title "Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide" @default.
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• W2019948763 doi "https://doi.org/10.1152/ajpcell.00547.2005" @default.
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