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- W2019948880 abstract "ObjectivesThis study aimed to determine if pneumococcal polysaccharide vaccine (PPV) could suppress allergic inflammation in an allergic rhinitis mouse model and to explore whether differences exist regarding the effect of PPV according to timing of administration. Subjects and MethodsBALB/c mice were divided into control, Der f, Pre-S, and Post-S groups. The allergen was Dermatophagoides farinae (Der f). Pneumococcal polysaccharide vaccine was administered before (Pre-S) or after (Post-S) sensitization. Allergic symptoms and eosinophils in nasal mucosa, interferon-γ, interleukin (IL)–13, and IL-10 in nasal lavage fluid and serum Der f–specific IgE were measured. T-bet, GATA-3, and Foxp3 mRNA in spleen were determined by real-time polymerase chain reaction. Flow cytometry of CD4+CD25+Foxp3+ T cells in spleen was analyzed. ResultsIn the Pre-S group, symptom score, serum Der f–specific IgE, eosinophils, IL-13, and GATA-3 mRNA were decreased (P < .05), and IL-10, Foxp3 mRNA, and CD4+CD25+Foxp3+ T cells were increased compared with those in Der f group (P < .05). In the Post-S group, symptom score, serum Der f–specific IgE, and GATA-3 mRNA were decreased (P < .05), and Foxp3 mRNA and CD4+CD25+Foxp3+ T cells were increased compared with those in the Der f group (P < .05). ConclusionThese results suggest that PPV administered before or after sensitization suppresses Th2 response and enhanced induction of regulatory T cells in an allergic rhinitis model. In addition, there was no significant difference between the degrees of effects in these 2 conditions. In the future, we can consider PPV to be a preventative agent for allergic rhinitis." @default.
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- W2019948880 date "2013-01-11" @default.
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- W2019948880 title "The Effect of Pneumococcal Polysaccharide Vaccine in a Mouse Model of Allergic Rhinitis" @default.
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- W2019948880 doi "https://doi.org/10.1177/0194599812472864" @default.
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