FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019950439> ?p ?o ?g. }

• W2019950439 endingPage "267" @default.
• W2019950439 startingPage "259" @default.
• W2019950439 abstract "The precise role of bone marrow adipose tissue (BMAT) in the marrow remains unknown. The purpose of the present study was therefore to describe a novel method for studying BMAT using 3‐D collagen gel culture of BMAT fragments, immunohistochemistry, ELISA and real‐time reverse transcription–polymerase chain reaction. Mature adipocytes and CD45+ leukocytes were retained for >3 weeks. Bone marrow stromal cells (BMSC) including a small number of lipid‐laden preadipocytes and CD44+/CD105+ mesenchymal stem cell (MSC)‐like cells, developed from BMAT. Dexamethasone (10 µmol/L), but not insulin (20 mU/mL), significantly increased the number of preadipocytes. Dexamethasone and insulin also promoted leptin production and gene expression in BMAT. Adiponectin production by BMAT was <0.8 ng/mL under all culture conditions. Dexamethasone promoted adiponectin gene expression, while insulin inhibited it. This finding suggests that dexamethasone, but not insulin, may serve as a powerful adipogenic factor for BMAT, in which adiponectin protein secretion is normally very low, and that BMAT may exhibit a different phenotype from that of the visceral and subcutaneous adipose tissues. BMAT–osteoblast interactions were also examined, and it was found that osteoblasts inhibited the development of BMSC and reduced leptin production, while BMAT inhibited the growth and differentiation of osteoblasts. The present novel method proved to be useful for the study of BMAT biology." @default.
• W2019950439 created "2016-06-24" @default.
• W2019950439 creator A5000036873 @default.
• W2019950439 creator A5000883892 @default.
• W2019950439 creator A5026332836 @default.
• W2019950439 creator A5026887120 @default.
• W2019950439 creator A5029788402 @default.
• W2019950439 creator A5035628885 @default.
• W2019950439 creator A5036437003 @default.
• W2019950439 creator A5053209113 @default.
• W2019950439 creator A5065318724 @default.
• W2019950439 creator A5081041527 @default.
• W2019950439 date "2010-03-17" @default.
• W2019950439 modified "2023-10-16" @default.
• W2019950439 title "Organotypic culture of human bone marrow adipose tissue" @default.
• W2019950439 cites W1633340712 @default.
• W2019950439 cites W1933045257 @default.
• W2019950439 cites W1972812480 @default.
• W2019950439 cites W1974831291 @default.
• W2019950439 cites W1983430158 @default.
• W2019950439 cites W1995357491 @default.
• W2019950439 cites W2004597281 @default.
• W2019950439 cites W2013576112 @default.
• W2019950439 cites W2014193291 @default.
• W2019950439 cites W2022404768 @default.
• W2019950439 cites W2029629119 @default.
• W2019950439 cites W2035809261 @default.
• W2019950439 cites W2040845651 @default.
• W2019950439 cites W2041846357 @default.
• W2019950439 cites W2047014086 @default.
• W2019950439 cites W2056508484 @default.
• W2019950439 cites W2077026831 @default.
• W2019950439 cites W2084152511 @default.
• W2019950439 cites W2107503723 @default.
• W2019950439 cites W2118590328 @default.
• W2019950439 cites W2123551029 @default.
• W2019950439 cites W2143000352 @default.
• W2019950439 cites W2218441948 @default.
• W2019950439 cites W4245570402 @default.
• W2019950439 doi "https://doi.org/10.1111/j.1440-1827.2010.02511.x" @default.
• W2019950439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20403027" @default.
• W2019950439 hasPublicationYear "2010" @default.
• W2019950439 type Work @default.
• W2019950439 sameAs 2019950439 @default.
• W2019950439 citedByCount "18" @default.
• W2019950439 countsByYear W20199504392013 @default.
• W2019950439 countsByYear W20199504392014 @default.
• W2019950439 countsByYear W20199504392016 @default.
• W2019950439 countsByYear W20199504392018 @default.
• W2019950439 countsByYear W20199504392019 @default.
• W2019950439 countsByYear W20199504392020 @default.
• W2019950439 countsByYear W20199504392021 @default.
• W2019950439 countsByYear W20199504392022 @default.
• W2019950439 countsByYear W20199504392023 @default.
• W2019950439 crossrefType "journal-article" @default.
• W2019950439 hasAuthorship W2019950439A5000036873 @default.
• W2019950439 hasAuthorship W2019950439A5000883892 @default.
• W2019950439 hasAuthorship W2019950439A5026332836 @default.
• W2019950439 hasAuthorship W2019950439A5026887120 @default.
• W2019950439 hasAuthorship W2019950439A5029788402 @default.
• W2019950439 hasAuthorship W2019950439A5035628885 @default.
• W2019950439 hasAuthorship W2019950439A5036437003 @default.
• W2019950439 hasAuthorship W2019950439A5053209113 @default.
• W2019950439 hasAuthorship W2019950439A5065318724 @default.
• W2019950439 hasAuthorship W2019950439A5081041527 @default.
• W2019950439 hasConcept C122927707 @default.
• W2019950439 hasConcept C126322002 @default.
• W2019950439 hasConcept C134018914 @default.
• W2019950439 hasConcept C16685009 @default.
• W2019950439 hasConcept C16930146 @default.
• W2019950439 hasConcept C171089720 @default.
• W2019950439 hasConcept C185592680 @default.
• W2019950439 hasConcept C198826908 @default.
• W2019950439 hasConcept C2776782570 @default.
• W2019950439 hasConcept C2777391703 @default.
• W2019950439 hasConcept C2779306644 @default.
• W2019950439 hasConcept C2780007613 @default.
• W2019950439 hasConcept C2780613262 @default.
• W2019950439 hasConcept C2780806160 @default.
• W2019950439 hasConcept C511355011 @default.
• W2019950439 hasConcept C71924100 @default.
• W2019950439 hasConcept C86803240 @default.
• W2019950439 hasConcept C95444343 @default.
• W2019950439 hasConceptScore W2019950439C122927707 @default.
• W2019950439 hasConceptScore W2019950439C126322002 @default.
• W2019950439 hasConceptScore W2019950439C134018914 @default.
• W2019950439 hasConceptScore W2019950439C16685009 @default.
• W2019950439 hasConceptScore W2019950439C16930146 @default.
• W2019950439 hasConceptScore W2019950439C171089720 @default.
• W2019950439 hasConceptScore W2019950439C185592680 @default.
• W2019950439 hasConceptScore W2019950439C198826908 @default.
• W2019950439 hasConceptScore W2019950439C2776782570 @default.
• W2019950439 hasConceptScore W2019950439C2777391703 @default.
• W2019950439 hasConceptScore W2019950439C2779306644 @default.
• W2019950439 hasConceptScore W2019950439C2780007613 @default.
• W2019950439 hasConceptScore W2019950439C2780613262 @default.
• W2019950439 hasConceptScore W2019950439C2780806160 @default.
• W2019950439 hasConceptScore W2019950439C511355011 @default.

• next