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• W2019950602 abstract "The cytokinesis-block micronucleus assay is increasingly being applied to the study of spontaneous or induced genetic damage in human lymphocytes, but little is known about dietary and other lifestyle factors that could influence this index. As part of a larger study investigating the role of dietary factors on baseline genetic damage in human lymphocytes, from 152 non-smoking females and 113 non-smoking males evenly distributed between the ages of 20 and 87 years, we have measured (a) the micronucleus (MN) frequency and (b) the plasma level of the anti-oxidant vitamins C and E and the B Vitamins folic acid and B12. Multiple regression analysis indicated that age (β value = 0.598, P < 0.0001) was the most important factor influencing the variance of micronucleus frequency in females, while micronutrient levels had no apparent significant effects on genetic damage. In males age was also the predominant factor (β Value= 0.505, P < 0.0001) influencing genetic damage, but vitamin-C level also contributed positively and significantly to the observed MN frequency (β value = 0.220, P < 0.0228). To avoid the potential confounding effect of collinearity between variables we also performed separate simple regression analysis for each plasma micronutrient in relation to age-adjusted micronucleus frequency; the results from this analysis again showed a significant and positive effect of plasma vitamin C on age-adjusted micronucleus frequency in males only (β value = 0.188, P = 0.0503), while no effect was observed for the other micronutrients in both sexes. In view of the predominant age effect, we also focused on the data obtained in the youngest age groups of both sexes (i.e. 20–30 years olds) and found (a) that the MN frequency in young males is significantly and positively correlated with plasma vitamin C levels (r = 0.823, P <0.001) but negatively correlated with plasma vitamin B12 status (r = -0.799, P < 0.001) and(b) in females the only significant correlation was an inverse relationship between MN frequency and the combined folate and vitamin B12 plasma levels (r = - 0.4632, P < 0.030). These data suggest that (a) important consideration should be given to the role of vitamin C in aggravating spontaneous genetic damage and the role of Vitamin B12 in maintaining genetic stability of lymphocytes in males and (b) that folic acid and vitamin B12 plasma levels within what is considered to be a normal range may not be optimal for minimizing genetic damage rates in lymphocytes of young females. It is also evident that epidemiological studies involving the use of genetic damage end-points cannot be considered seriously unless vitamin C, folic acid and vitamin B12 status is also measured in the survey." @default.
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• W2019950602 modified "2023-09-23" @default.
• W2019950602 title "The relationship between micronuclei in human lymphocytes and plasma levels of vitamin C, Vitamin E, Vitamin B₁₂ and folic acid" @default.
• W2019950602 doi "https://doi.org/10.1093/carcin/15.7.1405" @default.
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