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- W2019951710 abstract "The effects of tyrosine kinase inhibitors and non-selective cation channel blockers on capacitative Ca2+ entry were examined in the presence of methoxyverapamil in rat ileal smooth muscles. In Ca2+-free solution, carbachol or caffeine produced a rapid contraction mediated by Ca2+ release from the stores (Ca2+-release response), and then led to Ca2+ depletion of the stores. Subsequently, reintroduction of Ca2+ caused a transient contraction due to capacitative Ca2+ entry. Tyrosine kinase inhibitors, genistein and tyrphostin 47 but not herbimycin A, suppressed the responses to Ca2+-reintroduction much greater than Ca2+-release responses to carbachol or caffeine. Similar inhibitory effects on the responses to Ca2+-reintroduction were obtained with daidzein and tyrphostin A1, respective inactive analogue of genistein and tyrphostins. After continuous depletion of the stores with thapsigargin, Ca2+-reintroduction produced a sustained contraction, which was inhibited by these agents to different extents, but not by herbimycin A. In β-escin-treated skinned muscles, genistein slightly reduced Ca2+-induced contraction. In fura-2-loaded tissues, SK&F 96365 inhibited contractile and [Ca2+]i responses to Ca2+-reintroduction but minimally affected Ca2+-release responses. Tetrandrine suppressed both responses to Ca2+-reintroduction and to Ca2+-release. These results suggest that genistein and tyrphostin 47 inhibit capacitative Ca2+ entry through an inhibition of Ca2+ entry channels rather than tyrosine kinase. SK&F 96365, but not tetrandrine, seems to selectively inhibit the contractile responses to capacitative Ca2+ entry in rat ileal smooth muscles." @default.
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- W2019951710 date "2000-01-01" @default.
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- W2019951710 title "Effects of inhibitors for tyrosine kinase and non-selective cation channel on capacitative Ca2+ entry in rat ileal smooth muscle" @default.
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- W2019951710 doi "https://doi.org/10.1016/s0014-2999(99)00814-6" @default.
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