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- W2019952026 abstract "Abstract 1. (1) Membrane transport of 3-O- methyl- d [ 14 C]glucose and intracellular levels of Na+ and K+ were measured in “intact” rat hemidiaphragms, in vitro. 2. (2) Incubation in media with high K+ content led to decreased Na+ and increased K+ levels in the muscle cells, corresponding to stimulation of the Na+ pump. 3. (3) In parallel with the decrease in internal Na+ and increase in internal K+ levels, sugar transport both into and out of the cells was decreased. This effect was greater in the presence of a submaximal concentration of insulin but was also observed in its absence. 4. (4) “High-potassium” media were prepared by isosmotic substitution of K+ for Na+ or by addition of KCl to normal medium. The resulting decrease in external Na+ or increase in osmolarity, respectively, both stimulated sugar transport and partially counteracted the inhibitory effect of high K+. 5. (5) The inhibition of sugar transport by high K+ is the converse to the previously described stimulation of sugar transport following inhibition of the Na+ pump. The results thus support our earlier suggestion that the internal concentrations of Na+ and/or K+ may regulate sugar transport in muscle." @default.
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- W2019952026 title "Regulation of sugar transport in muscle: Effect of increased external potassium in vitro" @default.
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- W2019952026 doi "https://doi.org/10.1016/0005-2736(71)90030-7" @default.
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