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- W2019952151 abstract "The effects of age (19-100 years) upon dopamine uptake sites labeled with [3H]GBR-12935 in human postmortem putamen from 20 individuals were studied. There was a 70% decrease in binding density (Bmax) over the adult age range. No significant changes in binding affinity (Kd) were detected, the mean Kd being 1.0 +/- 0.2 nM (mean +/- S.E.M.). Nor were there any changes in binding related to the postmortem delay. Based on the findings that [3H]GBR-12935 labels the uptake site for dopamine, it is suggested that the age-related loss of [3H]GBR-12935 binding in human putamen reflects a degeneration of dopamine neurites." @default.
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- W2019952151 date "1989-11-01" @default.
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- W2019952151 title "Age-correlated loss of dopamine uptake sites labeled with [3H]GBR-12935 in human putamen" @default.
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- W2019952151 doi "https://doi.org/10.1016/0197-4580(89)90001-8" @default.
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