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- W2019952241 abstract "A series of bis-pyridinium cyclophane analogs designed as conformationally restricted bis-quaternary ammonium compounds were evaluated for their affinity for the blood–brain barrier (BBB) choline transporter. All the cyclophanes investigated exhibited high affinity compared to choline. Of these compounds, N, N′-(1,10-decanediyl)3,3′-(1,9-decadiyn-1,10-diyl)-bis-pyridinium diiodide (5c) and N,N′-(1,9-nonanediyl)3,3′-(1,9-decadiyn-1,10-diyl)-bis-pyridinium dibromide (5b) exhibited highest affinity with Ki values of 0.8 μM and 1.4 μM, respectively, and constitute some of the most potent BBB choline transporter ligands reported." @default.
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- W2019952241 date "2008-10-01" @default.
- W2019952241 modified "2023-10-18" @default.
- W2019952241 title "bis-Pyridinium cyclophanes: Novel ligands with high affinity for the blood–brain barrier choline transporter" @default.
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- W2019952241 doi "https://doi.org/10.1016/j.bmcl.2008.08.099" @default.
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