FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019952252> ?p ?o ?g. }

• W2019952252 endingPage "e0126413" @default.
• W2019952252 startingPage "e0126413" @default.
• W2019952252 abstract "Attitudes of healthcare professionals regarding spontaneous reporting of adverse drug reactions (ADRs) in Japan are not well known, and Japan's unique system of surveillance, called early post-marketing phase vigilance (EPPV), may affect these reporting attitudes. Our objectives were to describe potential effects of EPPV and to test whether ADR seriousness, prominence, and frequency are related to changes in reporting over time.A manufacturer's database of spontaneous ADR reports was used to extract data from individual case safety reports for 5 drugs subject to EPPV. The trend of reporting and the time lag between ADR onset and reporting to the manufacturer were examined. The following indices for ADRs occurring with each drug were calculated and analyzed to assess reporting trends: Serious:Non-serious ratio, High prominence:Low prominence ratio, and High frequency:Low frequency ratio.For all 5 drugs, the time lag between ADR onset and reporting to the manufacturer was shorter in the EPPV period than in the post-EPPV period. All drugs showed higher Serious:Non-serious ratios in the post-EPPV period. No specific patterns were observed for the High prominence:Low prominence ratio. The High frequency:Low frequency ratio for peginterferon alpha-2a and sevelamer hydrochloride decreased steadily throughout the study period.Healthcare professionals may be more likely to report serious ADRs than to report non-serious ADRs, but the effect of event prominence on reporting trends is still unclear. Factors associated with ADR reporting attitude in Japan might be different from those in other countries because of EPPV and the involvement of medical representatives in the spontaneous reporting process. Pharmacovigilance specialists should therefore be cautious when comparing data between different time periods or different countries. Further studies are needed to elucidate the underlying mechanism of spontaneous ADR reporting in Japan." @default.
• W2019952252 created "2016-06-24" @default.
• W2019952252 creator A5001695955 @default.
• W2019952252 creator A5032428957 @default.
• W2019952252 creator A5042600666 @default.
• W2019952252 creator A5045962358 @default.
• W2019952252 creator A5051592668 @default.
• W2019952252 creator A5055323152 @default.
• W2019952252 creator A5059605428 @default.
• W2019952252 creator A5062164321 @default.
• W2019952252 creator A5065326173 @default.
• W2019952252 creator A5078130412 @default.
• W2019952252 creator A5085822461 @default.
• W2019952252 date "2015-05-01" @default.
• W2019952252 modified "2023-10-17" @default.
• W2019952252 title "Bias in Spontaneous Reporting of Adverse Drug Reactions in Japan" @default.
• W2019952252 cites W122320840 @default.
• W2019952252 cites W1480848704 @default.
• W2019952252 cites W1489861263 @default.
• W2019952252 cites W1505546093 @default.
• W2019952252 cites W1698707290 @default.
• W2019952252 cites W2006236530 @default.
• W2019952252 cites W2009890917 @default.
• W2019952252 cites W2010118982 @default.
• W2019952252 cites W2015487160 @default.
• W2019952252 cites W2028461978 @default.
• W2019952252 cites W2058233269 @default.
• W2019952252 cites W2060615806 @default.
• W2019952252 cites W2061185877 @default.
• W2019952252 cites W2075362744 @default.
• W2019952252 cites W2085752173 @default.
• W2019952252 cites W2119156782 @default.
• W2019952252 cites W261240404 @default.
• W2019952252 cites W92929729 @default.
• W2019952252 cites W99141901 @default.
• W2019952252 doi "https://doi.org/10.1371/journal.pone.0126413" @default.
• W2019952252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4416713" @default.
• W2019952252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25933226" @default.
• W2019952252 hasPublicationYear "2015" @default.
• W2019952252 type Work @default.
• W2019952252 sameAs 2019952252 @default.
• W2019952252 citedByCount "27" @default.
• W2019952252 countsByYear W20199522522016 @default.
• W2019952252 countsByYear W20199522522017 @default.
• W2019952252 countsByYear W20199522522018 @default.
• W2019952252 countsByYear W20199522522019 @default.
• W2019952252 countsByYear W20199522522020 @default.
• W2019952252 countsByYear W20199522522021 @default.
• W2019952252 countsByYear W20199522522022 @default.
• W2019952252 countsByYear W20199522522023 @default.
• W2019952252 crossrefType "journal-article" @default.
• W2019952252 hasAuthorship W2019952252A5001695955 @default.
• W2019952252 hasAuthorship W2019952252A5032428957 @default.
• W2019952252 hasAuthorship W2019952252A5042600666 @default.
• W2019952252 hasAuthorship W2019952252A5045962358 @default.
• W2019952252 hasAuthorship W2019952252A5051592668 @default.
• W2019952252 hasAuthorship W2019952252A5055323152 @default.
• W2019952252 hasAuthorship W2019952252A5059605428 @default.
• W2019952252 hasAuthorship W2019952252A5062164321 @default.
• W2019952252 hasAuthorship W2019952252A5065326173 @default.
• W2019952252 hasAuthorship W2019952252A5078130412 @default.
• W2019952252 hasAuthorship W2019952252A5085822461 @default.
• W2019952252 hasBestOaLocation W20199522521 @default.
• W2019952252 hasConcept C105795698 @default.
• W2019952252 hasConcept C126322002 @default.
• W2019952252 hasConcept C156957248 @default.
• W2019952252 hasConcept C17744445 @default.
• W2019952252 hasConcept C197934379 @default.
• W2019952252 hasConcept C199539241 @default.
• W2019952252 hasConcept C2776650110 @default.
• W2019952252 hasConcept C2781342390 @default.
• W2019952252 hasConcept C33923547 @default.
• W2019952252 hasConcept C512399662 @default.
• W2019952252 hasConcept C57658597 @default.
• W2019952252 hasConcept C71924100 @default.
• W2019952252 hasConceptScore W2019952252C105795698 @default.
• W2019952252 hasConceptScore W2019952252C126322002 @default.
• W2019952252 hasConceptScore W2019952252C156957248 @default.
• W2019952252 hasConceptScore W2019952252C17744445 @default.
• W2019952252 hasConceptScore W2019952252C197934379 @default.
• W2019952252 hasConceptScore W2019952252C199539241 @default.
• W2019952252 hasConceptScore W2019952252C2776650110 @default.
• W2019952252 hasConceptScore W2019952252C2781342390 @default.
• W2019952252 hasConceptScore W2019952252C33923547 @default.
• W2019952252 hasConceptScore W2019952252C512399662 @default.
• W2019952252 hasConceptScore W2019952252C57658597 @default.
• W2019952252 hasConceptScore W2019952252C71924100 @default.
• W2019952252 hasIssue "5" @default.
• W2019952252 hasLocation W20199522521 @default.
• W2019952252 hasLocation W20199522522 @default.
• W2019952252 hasLocation W20199522523 @default.
• W2019952252 hasLocation W20199522524 @default.
• W2019952252 hasLocation W20199522525 @default.
• W2019952252 hasOpenAccess W2019952252 @default.
• W2019952252 hasPrimaryLocation W20199522521 @default.
• W2019952252 hasRelatedWork W2159420871 @default.
• W2019952252 hasRelatedWork W2793948734 @default.
• W2019952252 hasRelatedWork W2888809634 @default.

• next