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- W2019953102 abstract "Background Natalizumab is an approved drug used in relapsing and aggressive Multiple Sclerosis (MS). This is a monoclonal anti-integrin antibody that decreases the transmigration of immune cells through the blood-brain-barrier in animal models of MS. In human, the number of T cells in the CSF is dramatically decreased while the number of circulating lymphocytes usually increases. We hypothesized that in patients treated with natalizumab, the infiltration of T cells in the brain parenchyma decreases. These cells may accumulate in the blood of the patients and thus alter the T cell repertoire." @default.
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- W2019953102 date "2011-11-23" @default.
- W2019953102 modified "2023-10-02" @default.
- W2019953102 title "Natalizumab alters the TCR repertoire after one year of treatment in four MS patients" @default.
- W2019953102 doi "https://doi.org/10.1186/1479-5876-9-s2-p26" @default.
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