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- W2019954393 abstract "Abstract The effects of nicotine and other cholinergic drugs on the initial incorporation of 32 P i , and [ 3 H]glycerol into 1-phosphatidylinositol-4-phosphate(DPI)and 1-phosphatidylinsitol-3,4-bisphosphate (TPI) in the rat brain microsomal fraction were studied. Nicotine and eserine significantly decreased and mecamylamine increased [ 32 P]- and [ 3 H]TPI levels. Atropine had no effect on labeled TPI levels. Dose-effect studies for nicotine revealed that as little as 0.1 mg/kg of nicotine, i.p., significantly decreased the accumulation of labeled TPI. It was concluded that pharmacologically relevant and nonconvulsive doses of nicotine can markedly affect brain polyphosphoinositide synthesis and/or metabolism; the nature of the effects is consistent with theories suggesting that the conversion of TPI to DPI will release membrane lipid bound Ca 2+ and, thus, increase membrane excitability." @default.
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- W2019954393 date "1978-01-01" @default.
- W2019954393 modified "2023-09-27" @default.
- W2019954393 title "Effects of nicotine on brain 1-phosphatidylinositol-4-phosphate and 1-phosphatidylinositol-3,4-bisphosphate synthesis and metabolism—possible relationship to nicotine-induced behaviors" @default.
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- W2019954393 doi "https://doi.org/10.1016/0006-2952(78)90319-2" @default.
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