FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019954676> ?p ?o ?g. }

• W2019954676 endingPage "598" @default.
• W2019954676 startingPage "584" @default.
• W2019954676 abstract "Proprotein convertase 1 (PC1) is a neuroendocrine proteinase involved in the proteolytic activation of precursors to hormones and neuropeptides. To determine the physiological importance of PC1, we produced a mutant mouse from embryonic stem cells in which its locus (Pcsk1) had been inactivated by homologous recombination. The inactivating mutation consisted of a 32.7-kb internal deletion and a 1.8 kb insertion of the bacterial neomycin resistance gene (neo) under the mouse phosphoglycerate kinase 1 protein (PGKneo). Intercross of Pcsk1(+/-) mice produced no Pcsk1(-/-) offspring or blastocysts; in addition, more than 80% of the offspring were Pcsk1(+/-). These observations suggested that the mutation caused preimplantation lethality of homozygous embryos and preferential transmission of the mutant allele. Interestingly, RT-PCR analysis on RNA from endocrine tissues from Pcsk1(+/-) mice revealed the presence of aberrant transcripts specifying the N-terminal half of the PC1 propeptide fused to neo gene product. Mass spectrometric profiles of proopiomelanocortin-derived peptides in the anterior pituitary were similar between Pcsk1(+/-) and Pcsk1(+/+) mice, but significantly different between male and female mice of the same genotype. Relative to their wild-type counterparts, female mutant mice exhibited stunted growth under a low fat diet, and catch-up growth under a high-fat diet. The complex phenotype exhibited by this Pcsk1 mutant mouse model may be due to PC1 deficiency aggravated by expression of aberrant gene products from the mutant allele." @default.
• W2019954676 created "2016-06-24" @default.
• W2019954676 creator A5001556287 @default.
• W2019954676 creator A5002186564 @default.
• W2019954676 creator A5009035456 @default.
• W2019954676 creator A5056861344 @default.
• W2019954676 creator A5088398126 @default.
• W2019954676 creator A5088427605 @default.
• W2019954676 creator A5090995081 @default.
• W2019954676 date "2007-06-01" @default.
• W2019954676 modified "2023-10-01" @default.
• W2019954676 title "A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat" @default.
• W2019954676 cites W1503569939 @default.
• W2019954676 cites W1513564091 @default.
• W2019954676 cites W1517461798 @default.
• W2019954676 cites W1844798178 @default.
• W2019954676 cites W1892495821 @default.
• W2019954676 cites W1902317935 @default.
• W2019954676 cites W1940463576 @default.
• W2019954676 cites W1965574341 @default.
• W2019954676 cites W1966470012 @default.
• W2019954676 cites W1971463518 @default.
• W2019954676 cites W1973041446 @default.
• W2019954676 cites W1975536402 @default.
• W2019954676 cites W1977154588 @default.
• W2019954676 cites W1978419854 @default.
• W2019954676 cites W1987277509 @default.
• W2019954676 cites W1990498979 @default.
• W2019954676 cites W1993811128 @default.
• W2019954676 cites W1995934769 @default.
• W2019954676 cites W2000320917 @default.
• W2019954676 cites W2001045107 @default.
• W2019954676 cites W2007842896 @default.
• W2019954676 cites W2016628877 @default.
• W2019954676 cites W2018941771 @default.
• W2019954676 cites W2021949163 @default.
• W2019954676 cites W2022527113 @default.
• W2019954676 cites W2024752725 @default.
• W2019954676 cites W2025399103 @default.
• W2019954676 cites W2031196190 @default.
• W2019954676 cites W2034419609 @default.
• W2019954676 cites W2040475488 @default.
• W2019954676 cites W2040851473 @default.
• W2019954676 cites W2046820814 @default.
• W2019954676 cites W2047652128 @default.
• W2019954676 cites W2048187464 @default.
• W2019954676 cites W2058341758 @default.
• W2019954676 cites W2058791246 @default.
• W2019954676 cites W2062328606 @default.
• W2019954676 cites W2062808764 @default.
• W2019954676 cites W2062952618 @default.
• W2019954676 cites W2066463545 @default.
• W2019954676 cites W2069482043 @default.
• W2019954676 cites W2070721758 @default.
• W2019954676 cites W2082012658 @default.
• W2019954676 cites W2085545359 @default.
• W2019954676 cites W2089973146 @default.
• W2019954676 cites W2099336487 @default.
• W2019954676 cites W2103390969 @default.
• W2019954676 cites W2104102520 @default.
• W2019954676 cites W2106307038 @default.
• W2019954676 cites W2110901262 @default.
• W2019954676 cites W2111675794 @default.
• W2019954676 cites W2116303795 @default.
• W2019954676 cites W2116901594 @default.
• W2019954676 cites W2120032466 @default.
• W2019954676 cites W2122778024 @default.
• W2019954676 cites W2123704253 @default.
• W2019954676 cites W2125747464 @default.
• W2019954676 cites W2131904899 @default.
• W2019954676 cites W2137823340 @default.
• W2019954676 cites W2138612489 @default.
• W2019954676 cites W2151021554 @default.
• W2019954676 cites W2154166319 @default.
• W2019954676 cites W2160007926 @default.
• W2019954676 cites W2161084765 @default.
• W2019954676 cites W2164576092 @default.
• W2019954676 cites W2169293623 @default.
• W2019954676 cites W2187271679 @default.
• W2019954676 cites W2403189072 @default.
• W2019954676 cites W2945038622 @default.
• W2019954676 cites W39364543 @default.
• W2019954676 cites W4240896746 @default.
• W2019954676 cites W4247292500 @default.
• W2019954676 cites W4248411791 @default.
• W2019954676 cites W4253699883 @default.
• W2019954676 doi "https://doi.org/10.1016/j.ydbio.2007.03.523" @default.
• W2019954676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17490633" @default.
• W2019954676 hasPublicationYear "2007" @default.
• W2019954676 type Work @default.
• W2019954676 sameAs 2019954676 @default.
• W2019954676 citedByCount "33" @default.
• W2019954676 countsByYear W20199546762012 @default.
• W2019954676 countsByYear W20199546762013 @default.
• W2019954676 countsByYear W20199546762014 @default.
• W2019954676 countsByYear W20199546762016 @default.
• W2019954676 countsByYear W20199546762017 @default.
• W2019954676 countsByYear W20199546762018 @default.

• next