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• W2019955356 abstract "The question of whether hormonal contraception, particularly depot medroxyprogesterone acetate, increases a woman's risk of acquiring HIV has been debated since an association was first noted in 1991. 1 Plummer FA Simonsen JN Cameron DW et al. Cofactors in male-female sexual transmission of human immunodeficiency virus type 1. J Infect Dis. 1991; 163: 233-239 Crossref PubMed Scopus (618) Google Scholar Subsequent data from observational studies, secondary analyses of trials, and systematic reviews 2 Baeten JM Benki S Chohan V et al. Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women. AIDS. 2007; 21: 1771-1777 Crossref PubMed Scopus (132) Google Scholar , 3 Morrison CS Richardson BA Mmiro F et al. Hormonal contraception and the risk of HIV acquisition. AIDS. 2007; 21: 85-95 Crossref PubMed Scopus (178) Google Scholar , 4 Kleinschmidt I Rees H Delany S et al. Injectable progestin contraceptive use and risk of HIV infection in a South African family planning cohort. Contraception. 2007; 75: 461-467 Summary Full Text Full Text PDF PubMed Scopus (68) Google Scholar largely support the view that depot medroxyprogesterone acetate makes a moderate contribution to HIV risk. Efforts to synthesise existing evidence, however, have shown significant heterogeneity and serious, uncontrolled risk of confounding. 5 Westhoff CL Winikoff B DMPA and HIV: do we need a trial?. Contraception. 2014; 90: 353 Summary Full Text Full Text PDF PubMed Scopus (5) Google Scholar , 6 Polis CB Curtis KM Use of hormonal contraceptives and HIV acquisition in women: a systematic review of the epidemiological evidence. Lancet Infect Dis. 2013; 13: 797-808 Summary Full Text Full Text PDF PubMed Scopus (99) Google Scholar , 7 Polis CB Phillips SJ Curtis KM et al. Hormonal contraceptive methods and risk of HIV acquisition in women: a systematic review of epidemiological evidence. Contraception. 2014; 90: 360-390 Summary Full Text Full Text PDF PubMed Scopus (71) Google Scholar Hormonal contraceptive use and women's risk of HIV acquisition: a meta-analysis of observational studiesOur findings show a moderate increased risk of HIV acquisition for all women using depot medroxyprogesterone acetate, with a smaller increase in risk for women in the general population. Whether the risks of HIV observed in our study would merit complete withdrawal of depot medroxyprogesterone acetate needs to be balanced against the known benefits of a highly effective contraceptive. Full-Text PDF" @default.
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• W2019955356 date "2015-02-01" @default.
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• W2019955356 title "Broadening the debate over HIV and hormonal contraception" @default.
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