FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019956180> ?p ?o ?g. }

• W2019956180 endingPage "1223" @default.
• W2019956180 startingPage "1213" @default.
• W2019956180 abstract "Clozapine, an ideal antipsychotic drug for the treatment of resistant schizophrenia, is considered the most underutilised treatment for schizophrenia. However, safety concerns have been raised about clozapine-induced cardiotoxicity, which may lead to sudden death, particularly in young patients. The exact mechanism of clozapine cardiotoxicity has not yet been thoroughly studied. This study aimed to investigate the possible mechanisms of clozapine-induced cardiotoxicity in a rat model. Young male Wistar rats were treated with clozapine (10, 15 and 25 mg/kg/day, i.p.) for 21 days. Haemodynamic and echocardiographic studies were performed for assessment of cardiac functions. Heart sections were studied histopathologically and immunohistochemically. Serum and cardiac markers of cardiotoxicity, oxidative stress, inflammation and apoptosis were evaluated. Heart sections of CLZ-treated animals showed increased cardiac inflammation that correlated with the clozapine dose. Serum levels of CK-MB and LDH levels increased, as did cardiac levels of TNF-α, MDA, NO, myeloperoxidase (MPO), 8-OHdG, caspase-3 and NF-κB p65. In contrast, GSH levels and GSH-Px activity decreased. Furthermore, immunohistochemical examination of the heart sections showed positive immunostaining for both 3-nitrotyrosine and caspase-3 in all clozapine-treated groups. Clozapine, particularly in relatively high doses, has a clear cardiotoxic effect. This cardiotoxicity is accompanied by increased myocardial oxidative stress, inflammatory cytokines, DNA damage and apoptosis with attenuation in antioxidant defences, thus explaining the previously reported myocarditis and pericarditis during clozapine therapy in clinical studies." @default.
• W2019956180 created "2016-06-24" @default.
• W2019956180 creator A5029640435 @default.
• W2019956180 creator A5059611019 @default.
• W2019956180 date "2014-01-01" @default.
• W2019956180 modified "2023-10-11" @default.
• W2019956180 title "Clozapine-induced cardiotoxicity in rats: Involvement of tumour necrosis factor alpha, NF-κβ and caspase-3" @default.
• W2019956180 cites W1603120693 @default.
• W2019956180 cites W1911526379 @default.
• W2019956180 cites W1944627890 @default.
• W2019956180 cites W1966653214 @default.
• W2019956180 cites W1968536001 @default.
• W2019956180 cites W1970764899 @default.
• W2019956180 cites W1982586554 @default.
• W2019956180 cites W1987473028 @default.
• W2019956180 cites W1989285304 @default.
• W2019956180 cites W1990802251 @default.
• W2019956180 cites W1992124391 @default.
• W2019956180 cites W1998585885 @default.
• W2019956180 cites W2002952820 @default.
• W2019956180 cites W2005450615 @default.
• W2019956180 cites W2019951936 @default.
• W2019956180 cites W2030143787 @default.
• W2019956180 cites W2034791766 @default.
• W2019956180 cites W2037059734 @default.
• W2019956180 cites W2039293582 @default.
• W2019956180 cites W2039425202 @default.
• W2019956180 cites W2039601697 @default.
• W2019956180 cites W2041956415 @default.
• W2019956180 cites W2042850454 @default.
• W2019956180 cites W2043663106 @default.
• W2019956180 cites W2048540725 @default.
• W2019956180 cites W2050074228 @default.
• W2019956180 cites W2050526581 @default.
• W2019956180 cites W2050744280 @default.
• W2019956180 cites W2052172788 @default.
• W2019956180 cites W2053594008 @default.
• W2019956180 cites W2054776920 @default.
• W2019956180 cites W2055006506 @default.
• W2019956180 cites W2063103115 @default.
• W2019956180 cites W2072993766 @default.
• W2019956180 cites W2073690515 @default.
• W2019956180 cites W2074246037 @default.
• W2019956180 cites W2099821432 @default.
• W2019956180 cites W2101518804 @default.
• W2019956180 cites W2104633776 @default.
• W2019956180 cites W2104702757 @default.
• W2019956180 cites W2116038099 @default.
• W2019956180 cites W2126326715 @default.
• W2019956180 cites W2129423085 @default.
• W2019956180 cites W2138545726 @default.
• W2019956180 cites W2154820798 @default.
• W2019956180 cites W2156667932 @default.
• W2019956180 cites W2171387289 @default.
• W2019956180 cites W2266929960 @default.
• W2019956180 cites W2737714003 @default.
• W2019956180 cites W4252306215 @default.
• W2019956180 cites W2230041623 @default.
• W2019956180 doi "https://doi.org/10.1016/j.toxrep.2014.11.012" @default.
• W2019956180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5598316" @default.
• W2019956180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28962331" @default.
• W2019956180 hasPublicationYear "2014" @default.
• W2019956180 type Work @default.
• W2019956180 sameAs 2019956180 @default.
• W2019956180 citedByCount "21" @default.
• W2019956180 countsByYear W20199561802017 @default.
• W2019956180 countsByYear W20199561802019 @default.
• W2019956180 countsByYear W20199561802020 @default.
• W2019956180 countsByYear W20199561802021 @default.
• W2019956180 countsByYear W20199561802022 @default.
• W2019956180 countsByYear W20199561802023 @default.
• W2019956180 crossrefType "journal-article" @default.
• W2019956180 hasAuthorship W2019956180A5029640435 @default.
• W2019956180 hasAuthorship W2019956180A5059611019 @default.
• W2019956180 hasBestOaLocation W20199561801 @default.
• W2019956180 hasConcept C118552586 @default.
• W2019956180 hasConcept C126322002 @default.
• W2019956180 hasConcept C134018914 @default.
• W2019956180 hasConcept C2776151105 @default.
• W2019956180 hasConcept C2776412080 @default.
• W2019956180 hasConcept C2776914184 @default.
• W2019956180 hasConcept C2778233292 @default.
• W2019956180 hasConcept C2780864610 @default.
• W2019956180 hasConcept C2780875844 @default.
• W2019956180 hasConcept C2781001862 @default.
• W2019956180 hasConcept C29730261 @default.
• W2019956180 hasConcept C71924100 @default.
• W2019956180 hasConcept C98274493 @default.
• W2019956180 hasConceptScore W2019956180C118552586 @default.
• W2019956180 hasConceptScore W2019956180C126322002 @default.
• W2019956180 hasConceptScore W2019956180C134018914 @default.
• W2019956180 hasConceptScore W2019956180C2776151105 @default.
• W2019956180 hasConceptScore W2019956180C2776412080 @default.
• W2019956180 hasConceptScore W2019956180C2776914184 @default.
• W2019956180 hasConceptScore W2019956180C2778233292 @default.
• W2019956180 hasConceptScore W2019956180C2780864610 @default.
• W2019956180 hasConceptScore W2019956180C2780875844 @default.
• W2019956180 hasConceptScore W2019956180C2781001862 @default.

• next