FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019956248> ?p ?o ?g. }

• W2019956248 abstract "The mitochondrial ADP/ATP carrier imports ADP from the cytosol and exports ATP from the mitochondrial matrix. The carrier cycles by an unresolved mechanism between the cytoplasmic state, in which the carrier accepts ADP from the cytoplasm, and the matrix state, in which it accepts ATP from the mitochondrial matrix. Here we present the structures of the yeast ADP/ATP carriers Aac2p and Aac3p in the cytoplasmic state. The carriers have three domains and are closed at the matrix side by three interdomain salt-bridge interactions, one of which is braced by a glutamine residue. Glutamine braces are conserved in mitochondrial carriers and contribute to an energy barrier, preventing the conversion to the matrix state unless substrate binding occurs. At the cytoplasmic side a second salt-bridge network forms during the transport cycle, as demonstrated by functional analysis of mutants with charge-reversed networks. Analyses of the domain structures and properties of the interdomain interfaces indicate that interconversion between states involves movement of the even-numbered α-helices across the surfaces of the odd-numbered α-helices by rotation of the domains. The odd-numbered α-helices have an L-shape, with proline or serine residues at the kinks, which functions as a lever-arm, coupling the substrate-induced disruption of the matrix network to the formation of the cytoplasmic network. The simultaneous movement of three domains around a central translocation pathway constitutes a unique mechanism among transport proteins. These findings provide a structural description of transport by mitochondrial carrier proteins, consistent with an alternating-access mechanism." @default.
• W2019956248 created "2016-06-24" @default.
• W2019956248 creator A5006839481 @default.
• W2019956248 creator A5038380709 @default.
• W2019956248 creator A5039982154 @default.
• W2019956248 creator A5060409942 @default.
• W2019956248 creator A5067634666 @default.
• W2019956248 creator A5072603102 @default.
• W2019956248 date "2014-01-13" @default.
• W2019956248 modified "2023-10-18" @default.
• W2019956248 title "Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism" @default.
• W2019956248 cites W1482057189 @default.
• W2019956248 cites W1503898309 @default.
• W2019956248 cites W1533390549 @default.
• W2019956248 cites W1563385468 @default.
• W2019956248 cites W1690961319 @default.
• W2019956248 cites W1975604835 @default.
• W2019956248 cites W1976113016 @default.
• W2019956248 cites W1976167616 @default.
• W2019956248 cites W1981163058 @default.
• W2019956248 cites W1982705299 @default.
• W2019956248 cites W1983773833 @default.
• W2019956248 cites W1990515637 @default.
• W2019956248 cites W1994373739 @default.
• W2019956248 cites W1997432723 @default.
• W2019956248 cites W2000388754 @default.
• W2019956248 cites W2000844947 @default.
• W2019956248 cites W2006353505 @default.
• W2019956248 cites W2006692736 @default.
• W2019956248 cites W2009493983 @default.
• W2019956248 cites W2009636878 @default.
• W2019956248 cites W2010870281 @default.
• W2019956248 cites W2021969604 @default.
• W2019956248 cites W2022534606 @default.
• W2019956248 cites W2023679821 @default.
• W2019956248 cites W2024087232 @default.
• W2019956248 cites W2024269576 @default.
• W2019956248 cites W2027301728 @default.
• W2019956248 cites W2029144840 @default.
• W2019956248 cites W2036630715 @default.
• W2019956248 cites W2039774074 @default.
• W2019956248 cites W2043967644 @default.
• W2019956248 cites W2046790183 @default.
• W2019956248 cites W2060059149 @default.
• W2019956248 cites W2061125988 @default.
• W2019956248 cites W2062529809 @default.
• W2019956248 cites W2069129416 @default.
• W2019956248 cites W2075082852 @default.
• W2019956248 cites W2075921417 @default.
• W2019956248 cites W2076542263 @default.
• W2019956248 cites W2080349528 @default.
• W2019956248 cites W2083601687 @default.
• W2019956248 cites W2087024745 @default.
• W2019956248 cites W2087215431 @default.
• W2019956248 cites W2090273260 @default.
• W2019956248 cites W2095030312 @default.
• W2019956248 cites W2095558833 @default.
• W2019956248 cites W2095960563 @default.
• W2019956248 cites W2105370173 @default.
• W2019956248 cites W2166371650 @default.
• W2019956248 cites W2167891484 @default.
• W2019956248 cites W2169054000 @default.
• W2019956248 cites W4210283835 @default.
• W2019956248 doi "https://doi.org/10.1073/pnas.1320692111" @default.
• W2019956248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3910652" @default.
• W2019956248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24474793" @default.
• W2019956248 hasPublicationYear "2014" @default.
• W2019956248 type Work @default.
• W2019956248 sameAs 2019956248 @default.
• W2019956248 citedByCount "174" @default.
• W2019956248 countsByYear W20199562482014 @default.
• W2019956248 countsByYear W20199562482015 @default.
• W2019956248 countsByYear W20199562482016 @default.
• W2019956248 countsByYear W20199562482017 @default.
• W2019956248 countsByYear W20199562482018 @default.
• W2019956248 countsByYear W20199562482019 @default.
• W2019956248 countsByYear W20199562482020 @default.
• W2019956248 countsByYear W20199562482021 @default.
• W2019956248 countsByYear W20199562482022 @default.
• W2019956248 countsByYear W20199562482023 @default.
• W2019956248 crossrefType "journal-article" @default.
• W2019956248 hasAuthorship W2019956248A5006839481 @default.
• W2019956248 hasAuthorship W2019956248A5038380709 @default.
• W2019956248 hasAuthorship W2019956248A5039982154 @default.
• W2019956248 hasAuthorship W2019956248A5060409942 @default.
• W2019956248 hasAuthorship W2019956248A5067634666 @default.
• W2019956248 hasAuthorship W2019956248A5072603102 @default.
• W2019956248 hasBestOaLocation W20199562481 @default.
• W2019956248 hasConcept C104317684 @default.
• W2019956248 hasConcept C11701378 @default.
• W2019956248 hasConcept C12554922 @default.
• W2019956248 hasConcept C143065580 @default.
• W2019956248 hasConcept C145488412 @default.
• W2019956248 hasConcept C146587185 @default.
• W2019956248 hasConcept C181199279 @default.
• W2019956248 hasConcept C185592680 @default.
• W2019956248 hasConcept C190062978 @default.
• W2019956248 hasConcept C28859421 @default.
• W2019956248 hasConcept C30765947 @default.
• W2019956248 hasConcept C547475151 @default.

• next