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- W2019956469 endingPage "304" @default.
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- W2019956469 abstract "Introduction: Intensive efforts, over the last decade, have been made to inhibit the kinase activity of cyclins that act as mediators during cell-cycle progression. Activation of the cyclin D1 oncogene, often by amplification or rearrangement, is a major driver of multiple types of human tumors including breast and squamous cell cancers, B-cell lymphoma, myeloma and parathyroid adenoma. Areas covered: In this review, the authors summarize the activity of cyclins and cyclin-dependent kinases in cell-cycle progression and transcription. They focus on cyclin D1/CDK4/CDK6, a central mediator in the transition from G1 to S phase. Furthermore, the authors discuss the first generation of pan-cyclin-dependent kinase inhibitors that failed to meet expectation and discuss, in detail, the second generation of highly specific cyclin D1/CDK4/CDK6 inhibitors that are proving to be more efficacious. Expert opinion: The mechanism by which cyclin D1 drives tumorigenesis may be dependent on kinase and kinase-independent functions. Further evidence is necessary to delineate the roles of cyclin D1 in early pre-neoplastic lesions where its overexpression may promote genomic instability in a kinase-independent manner." @default.
- W2019956469 created "2016-06-24" @default.
- W2019956469 creator A5016235708 @default.
- W2019956469 creator A5029197376 @default.
- W2019956469 creator A5036720067 @default.
- W2019956469 creator A5049825258 @default.
- W2019956469 date "2014-01-03" @default.
- W2019956469 modified "2023-10-17" @default.
- W2019956469 title "Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present" @default.
- W2019956469 cites W1527674890 @default.
- W2019956469 cites W1752089945 @default.
- W2019956469 cites W1777065333 @default.
- W2019956469 cites W1968481186 @default.
- W2019956469 cites W1977340592 @default.
- W2019956469 cites W1982622947 @default.
- W2019956469 cites W1987597886 @default.
- W2019956469 cites W1988043615 @default.
- W2019956469 cites W1989077543 @default.
- W2019956469 cites W1990427876 @default.
- W2019956469 cites W1991550920 @default.
- W2019956469 cites W1994082723 @default.
- W2019956469 cites W1995038735 @default.
- W2019956469 cites W1995246165 @default.
- W2019956469 cites W1998187004 @default.
- W2019956469 cites W2004000621 @default.
- W2019956469 cites W2004391147 @default.
- W2019956469 cites W2005156019 @default.
- W2019956469 cites W2005722441 @default.
- W2019956469 cites W2007174523 @default.
- W2019956469 cites W2011207690 @default.
- W2019956469 cites W2011247719 @default.
- W2019956469 cites W2012820569 @default.
- W2019956469 cites W2015459776 @default.
- W2019956469 cites W2017120709 @default.
- W2019956469 cites W2017894431 @default.
- W2019956469 cites W2020331107 @default.
- W2019956469 cites W2028666395 @default.
- W2019956469 cites W2030800943 @default.
- W2019956469 cites W2035309762 @default.
- W2019956469 cites W2037139254 @default.
- W2019956469 cites W2037814326 @default.
- W2019956469 cites W2038596114 @default.
- W2019956469 cites W2041643931 @default.
- W2019956469 cites W2045156702 @default.
- W2019956469 cites W2045959839 @default.
- W2019956469 cites W2046024621 @default.
- W2019956469 cites W2048721919 @default.
- W2019956469 cites W2050941854 @default.
- W2019956469 cites W2052465225 @default.
- W2019956469 cites W2055576683 @default.
- W2019956469 cites W2058297051 @default.
- W2019956469 cites W2058705034 @default.
- W2019956469 cites W2058879820 @default.
- W2019956469 cites W2060323540 @default.
- W2019956469 cites W2060334131 @default.
- W2019956469 cites W2063329265 @default.
- W2019956469 cites W2064362422 @default.
- W2019956469 cites W2064937786 @default.
- W2019956469 cites W2068636366 @default.
- W2019956469 cites W2074918415 @default.
- W2019956469 cites W2075152619 @default.
- W2019956469 cites W2078502999 @default.
- W2019956469 cites W2082030057 @default.
- W2019956469 cites W2083573486 @default.
- W2019956469 cites W2085648789 @default.
- W2019956469 cites W2086641174 @default.
- W2019956469 cites W2089528428 @default.
- W2019956469 cites W2090945807 @default.
- W2019956469 cites W2093995506 @default.
- W2019956469 cites W2095610371 @default.
- W2019956469 cites W2098953839 @default.
- W2019956469 cites W2099011152 @default.
- W2019956469 cites W2101852594 @default.
- W2019956469 cites W2102140136 @default.
- W2019956469 cites W2103931447 @default.
- W2019956469 cites W2105707275 @default.
- W2019956469 cites W2106762061 @default.
- W2019956469 cites W2107570915 @default.
- W2019956469 cites W2108499089 @default.
- W2019956469 cites W2108958930 @default.
- W2019956469 cites W2109434236 @default.
- W2019956469 cites W2110793625 @default.
- W2019956469 cites W2112979110 @default.
- W2019956469 cites W2115692032 @default.
- W2019956469 cites W2116864752 @default.
- W2019956469 cites W2120633040 @default.
- W2019956469 cites W2121619780 @default.
- W2019956469 cites W2126553652 @default.
- W2019956469 cites W2126597686 @default.
- W2019956469 cites W2126821691 @default.
- W2019956469 cites W2129138172 @default.
- W2019956469 cites W2130019032 @default.
- W2019956469 cites W2132726386 @default.
- W2019956469 cites W2133959309 @default.
- W2019956469 cites W2134331780 @default.
- W2019956469 cites W2134590240 @default.
- W2019956469 cites W2136158663 @default.
- W2019956469 cites W2136369251 @default.