FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019957383> ?p ?o ?g. }

• W2019957383 endingPage "117" @default.
• W2019957383 startingPage "103" @default.
• W2019957383 abstract "Myocardial infarct via occlusion of the left anterior descending coronary in rats caused overriding depression in transcription, signal transduction, inflammation and extracellular matrix pathways in the infarct zone within 24 h. In contrast, remote zone gene expression was reciprocally activated during the immediate post-infarct period. Infarct zone signal transduction occurred primarily through TGFbeta1 induction while the remote zone exhibited elevated WNT, NOTCH, GPCR and transmembrane signaling. A minimal day 1 acute phase, inflammatory response was detected in the infarct zone while interleukins (IL1alpha, IL1beta, IL6, IL12alpha, IL18) and the TNFalpha superfamily were activated in the remote zone. Different cytochrome subsets were activated in each left ventricular region on day 1 while anti-oxidant genes were elevated only in the remote zone. The infarct zone exhibited mixed early transcription factor activation across all binding domains with a balance favoring constitutive gene activation and differentiation pathways as opposed to cell proliferation. In contrast, the remote zone exhibited activation of extensive developmental transcription factors involved in specification of cell phenotype, tissue-specific interactions and position-specific cell proliferation on day 1. The day 28 infarct zone response mirrored the day 1 remote zone response including activation of genes associated with matrix remodeling (metallothionein and metalloproteinase 9, 12, 23), as well as genes associated with cell proliferation and phenotype specification (MYC, EGR2, ATF3, HOXA1) recapitulating developmental histogenesis programs." @default.
• W2019957383 created "2016-06-24" @default.
• W2019957383 creator A5009108315 @default.
• W2019957383 creator A5014305512 @default.
• W2019957383 creator A5023880839 @default.
• W2019957383 creator A5026903972 @default.
• W2019957383 creator A5032609347 @default.
• W2019957383 creator A5043408006 @default.
• W2019957383 creator A5044666104 @default.
• W2019957383 creator A5045610376 @default.
• W2019957383 creator A5049337144 @default.
• W2019957383 creator A5070155048 @default.
• W2019957383 date "2005-01-01" @default.
• W2019957383 modified "2023-09-23" @default.
• W2019957383 title "Molecular dynamics of the compensatory response to myocardial infarct" @default.
• W2019957383 cites W1889002087 @default.
• W2019957383 cites W1990224341 @default.
• W2019957383 cites W1994734582 @default.
• W2019957383 cites W2002819948 @default.
• W2019957383 cites W2006194591 @default.
• W2019957383 cites W2006254974 @default.
• W2019957383 cites W2013945682 @default.
• W2019957383 cites W2036876430 @default.
• W2019957383 cites W2039601697 @default.
• W2019957383 cites W2050744280 @default.
• W2019957383 cites W2081309229 @default.
• W2019957383 cites W2081544530 @default.
• W2019957383 cites W2096161760 @default.
• W2019957383 cites W2098664089 @default.
• W2019957383 cites W2103026089 @default.
• W2019957383 cites W2122683221 @default.
• W2019957383 cites W2136418621 @default.
• W2019957383 cites W2151148996 @default.
• W2019957383 cites W2154401382 @default.
• W2019957383 cites W2157795344 @default.
• W2019957383 cites W2164619944 @default.
• W2019957383 cites W2166442426 @default.
• W2019957383 doi "https://doi.org/10.1016/j.yjmcc.2004.09.011" @default.
• W2019957383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15623427" @default.
• W2019957383 hasPublicationYear "2005" @default.
• W2019957383 type Work @default.
• W2019957383 sameAs 2019957383 @default.
• W2019957383 citedByCount "45" @default.
• W2019957383 countsByYear W20199573832012 @default.
• W2019957383 countsByYear W20199573832013 @default.
• W2019957383 countsByYear W20199573832014 @default.
• W2019957383 countsByYear W20199573832015 @default.
• W2019957383 countsByYear W20199573832016 @default.
• W2019957383 countsByYear W20199573832020 @default.
• W2019957383 countsByYear W20199573832021 @default.
• W2019957383 crossrefType "journal-article" @default.
• W2019957383 hasAuthorship W2019957383A5009108315 @default.
• W2019957383 hasAuthorship W2019957383A5014305512 @default.
• W2019957383 hasAuthorship W2019957383A5023880839 @default.
• W2019957383 hasAuthorship W2019957383A5026903972 @default.
• W2019957383 hasAuthorship W2019957383A5032609347 @default.
• W2019957383 hasAuthorship W2019957383A5043408006 @default.
• W2019957383 hasAuthorship W2019957383A5044666104 @default.
• W2019957383 hasAuthorship W2019957383A5045610376 @default.
• W2019957383 hasAuthorship W2019957383A5049337144 @default.
• W2019957383 hasAuthorship W2019957383A5070155048 @default.
• W2019957383 hasConcept C101762097 @default.
• W2019957383 hasConcept C102280478 @default.
• W2019957383 hasConcept C104317684 @default.
• W2019957383 hasConcept C137620995 @default.
• W2019957383 hasConcept C150194340 @default.
• W2019957383 hasConcept C157880135 @default.
• W2019957383 hasConcept C189165786 @default.
• W2019957383 hasConcept C54355233 @default.
• W2019957383 hasConcept C62478195 @default.
• W2019957383 hasConcept C86339819 @default.
• W2019957383 hasConcept C86803240 @default.
• W2019957383 hasConcept C95444343 @default.
• W2019957383 hasConceptScore W2019957383C101762097 @default.
• W2019957383 hasConceptScore W2019957383C102280478 @default.
• W2019957383 hasConceptScore W2019957383C104317684 @default.
• W2019957383 hasConceptScore W2019957383C137620995 @default.
• W2019957383 hasConceptScore W2019957383C150194340 @default.
• W2019957383 hasConceptScore W2019957383C157880135 @default.
• W2019957383 hasConceptScore W2019957383C189165786 @default.
• W2019957383 hasConceptScore W2019957383C54355233 @default.
• W2019957383 hasConceptScore W2019957383C62478195 @default.
• W2019957383 hasConceptScore W2019957383C86339819 @default.
• W2019957383 hasConceptScore W2019957383C86803240 @default.
• W2019957383 hasConceptScore W2019957383C95444343 @default.
• W2019957383 hasIssue "1" @default.
• W2019957383 hasLocation W20199573831 @default.
• W2019957383 hasLocation W20199573832 @default.
• W2019957383 hasOpenAccess W2019957383 @default.
• W2019957383 hasPrimaryLocation W20199573831 @default.
• W2019957383 hasRelatedWork W1986032432 @default.
• W2019957383 hasRelatedWork W2002515131 @default.
• W2019957383 hasRelatedWork W2024836429 @default.
• W2019957383 hasRelatedWork W2029606032 @default.
• W2019957383 hasRelatedWork W2094708072 @default.
• W2019957383 hasRelatedWork W2123037811 @default.
• W2019957383 hasRelatedWork W2370215344 @default.
• W2019957383 hasRelatedWork W2411612648 @default.

• next