Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019958571> ?p ?o ?g. }
- W2019958571 endingPage "61" @default.
- W2019958571 startingPage "53" @default.
- W2019958571 abstract "The insulin-like growth factor binding proteins (IGFBPs) represent a unique class of IGF antagonists regulating the bioavailability of the IGFs extracellularly. Accordingly, they represent an important class of proteins for cancer therapeutics and chemoprevention. IGF-F1-1 is a cyclic hexadecapeptide identified by high throughput phage display that binds to the IGFBP-binding domain on IGF-1. It acts as an IGFBP-mimetic, capable of inhibiting IGF-1 binding to the IGFBPs. To further examine the utility of IGF-F1-1 as an IGF-1 antagonist we tested its ability to inhibit IGFBP-2 and IGFBP-3 binding to IGF-1, (125)I-IGF-1 binding to IGF-1Rs and to block IGF-1 induced Akt activation, cell cycle changes and [(3)H]thymidine incorporation in MCF-7 cells. These biological activities were inhibited by treatment with IGFBP-2, wortmannin or the IGF-1R tyrosine kinase inhibitor, NVP-AEW541, but not by IGF-F1-1. Our findings confirm previous studies indicating that IGF-F1-1 is a weak antagonist of IGF-1 binding to the IGFBPs and the IGF-1R and suggest that it does not effectively inhibit downstream events stimulated by IGF-1. We further demonstrated that IGF-F1-1 treatment of MCF-7 cells results in the paradoxical activation of Akt, S-phase transition and [(3)H]thymidine incorporation. These results suggest that IGF-F1-1 is a weak agonist, exhibiting mitogenic actions. IGF-F1-1 may act in conjunction with IGF-1 at the IGF-1R or independently of IGF-1 at the IGF-1R or another receptor." @default.
- W2019958571 created "2016-06-24" @default.
- W2019958571 creator A5030274675 @default.
- W2019958571 creator A5087556038 @default.
- W2019958571 date "2006-06-01" @default.
- W2019958571 modified "2023-09-23" @default.
- W2019958571 title "Paradoxical effects of the phage display-derived peptide antagonist IGF-F1-1 on insulin-like growth factor-1 receptor signaling" @default.
- W2019958571 cites W1569741533 @default.
- W2019958571 cites W1602528313 @default.
- W2019958571 cites W1932898120 @default.
- W2019958571 cites W1969898679 @default.
- W2019958571 cites W1970298972 @default.
- W2019958571 cites W1978075691 @default.
- W2019958571 cites W1989527063 @default.
- W2019958571 cites W1999030960 @default.
- W2019958571 cites W2001447115 @default.
- W2019958571 cites W2007043599 @default.
- W2019958571 cites W2009876678 @default.
- W2019958571 cites W2012940389 @default.
- W2019958571 cites W2013932846 @default.
- W2019958571 cites W2020636054 @default.
- W2019958571 cites W2021140576 @default.
- W2019958571 cites W2023842143 @default.
- W2019958571 cites W2026790929 @default.
- W2019958571 cites W2036763753 @default.
- W2019958571 cites W2041058556 @default.
- W2019958571 cites W2043576320 @default.
- W2019958571 cites W2049480315 @default.
- W2019958571 cites W2049743105 @default.
- W2019958571 cites W2065153768 @default.
- W2019958571 cites W2066448449 @default.
- W2019958571 cites W2088906557 @default.
- W2019958571 cites W2098547168 @default.
- W2019958571 cites W2100970263 @default.
- W2019958571 cites W2111843196 @default.
- W2019958571 cites W2116343151 @default.
- W2019958571 cites W2117350664 @default.
- W2019958571 cites W2128412799 @default.
- W2019958571 cites W2133725782 @default.
- W2019958571 cites W2137395664 @default.
- W2019958571 cites W2143999338 @default.
- W2019958571 cites W2150081825 @default.
- W2019958571 cites W2151499061 @default.
- W2019958571 cites W2159318197 @default.
- W2019958571 cites W2160835537 @default.
- W2019958571 cites W2161699770 @default.
- W2019958571 doi "https://doi.org/10.1016/j.bcp.2006.03.025" @default.
- W2019958571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16684509" @default.
- W2019958571 hasPublicationYear "2006" @default.
- W2019958571 type Work @default.
- W2019958571 sameAs 2019958571 @default.
- W2019958571 citedByCount "7" @default.
- W2019958571 countsByYear W20199585712012 @default.
- W2019958571 countsByYear W20199585712014 @default.
- W2019958571 countsByYear W20199585712018 @default.
- W2019958571 crossrefType "journal-article" @default.
- W2019958571 hasAuthorship W2019958571A5030274675 @default.
- W2019958571 hasAuthorship W2019958571A5087556038 @default.
- W2019958571 hasConcept C126322002 @default.
- W2019958571 hasConcept C134018914 @default.
- W2019958571 hasConcept C144174609 @default.
- W2019958571 hasConcept C170493617 @default.
- W2019958571 hasConcept C2775960820 @default.
- W2019958571 hasConcept C2776165026 @default.
- W2019958571 hasConcept C2776885963 @default.
- W2019958571 hasConcept C2778308172 @default.
- W2019958571 hasConcept C2780378035 @default.
- W2019958571 hasConcept C2780689927 @default.
- W2019958571 hasConcept C55493867 @default.
- W2019958571 hasConcept C62478195 @default.
- W2019958571 hasConcept C71924100 @default.
- W2019958571 hasConcept C75217442 @default.
- W2019958571 hasConcept C86803240 @default.
- W2019958571 hasConcept C95444343 @default.
- W2019958571 hasConceptScore W2019958571C126322002 @default.
- W2019958571 hasConceptScore W2019958571C134018914 @default.
- W2019958571 hasConceptScore W2019958571C144174609 @default.
- W2019958571 hasConceptScore W2019958571C170493617 @default.
- W2019958571 hasConceptScore W2019958571C2775960820 @default.
- W2019958571 hasConceptScore W2019958571C2776165026 @default.
- W2019958571 hasConceptScore W2019958571C2776885963 @default.
- W2019958571 hasConceptScore W2019958571C2778308172 @default.
- W2019958571 hasConceptScore W2019958571C2780378035 @default.
- W2019958571 hasConceptScore W2019958571C2780689927 @default.
- W2019958571 hasConceptScore W2019958571C55493867 @default.
- W2019958571 hasConceptScore W2019958571C62478195 @default.
- W2019958571 hasConceptScore W2019958571C71924100 @default.
- W2019958571 hasConceptScore W2019958571C75217442 @default.
- W2019958571 hasConceptScore W2019958571C86803240 @default.
- W2019958571 hasConceptScore W2019958571C95444343 @default.
- W2019958571 hasIssue "1" @default.
- W2019958571 hasLocation W20199585711 @default.
- W2019958571 hasLocation W20199585712 @default.
- W2019958571 hasOpenAccess W2019958571 @default.
- W2019958571 hasPrimaryLocation W20199585711 @default.
- W2019958571 hasRelatedWork W2016564814 @default.
- W2019958571 hasRelatedWork W2078978316 @default.
- W2019958571 hasRelatedWork W2087090518 @default.