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- W2019959771 abstract "Abstract Aging results in a decrease in the maximum heart rate during exercise. To determine if the age-associated decline in maximal heart rate might be due to a decreased chronotropic response to catecholamines, the maximum heart rate induced by systemic injections of isoproterenol was compared in unanesthetized mature (1–4 year) and senescent (8–12 year) beagle dogs. Maximum rate was also assessed under pentobarbital anesthesia before and after cholinergic blockade with atropine. The unanesthetized baseline heart rates in the mature and senescent groups did not differ [148 ± 6 vs. 147 ± 7 beats/min (bpm)] but the maximum isoproterenol induced heart rate was lower in the senescent compared to the mature group (249 ± 7 vs. 286 ± 13 bpm, P" @default.
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- W2019959771 date "1979-04-01" @default.
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- W2019959771 title "Age-associated decrease in heart rate response to isoproterenol in dogs" @default.
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- W2019959771 doi "https://doi.org/10.1016/0047-6374(79)90067-8" @default.
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