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- W2019960592 abstract "A series of silver(I) complexes of 2,4-dihydroxybenzaldehyde-amino acid Schiff bases were designed and tested for α-glucosidase inhibition. Our results indicate that all the silver complexes (4a-18a) possessed strong inhibitory activity at μmolL(-1) level, especially glutamine (12a) and histidine (18a) Schiff base silver(I) complexes exhibited an IC50 value of less than 0.01μmolL(-1). This series of compounds exhibited noncompetitive inhibition characteristics in kinetic studies. In addition, we investigated the mechanism of inhibition and the structure-activity relationships of the amino acid Schiff base silver complexes. Our results reveal that Schiff base silver complexes may be explored for their therapeutic potential as alternatives of α-glucosidase inhibitors." @default.
- W2019960592 created "2016-06-24" @default.
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- W2019960592 date "2015-05-01" @default.
- W2019960592 modified "2023-09-25" @default.
- W2019960592 title "Silver(I) complexes of 2,4-dihydroxybenzaldehyde–amino acid Schiff bases—Novel noncompetitive α-glucosidase inhibitors" @default.
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- W2019960592 doi "https://doi.org/10.1016/j.bmcl.2015.03.078" @default.
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