FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019962671> ?p ?o ?g. }

• W2019962671 endingPage "456" @default.
• W2019962671 startingPage "441" @default.
• W2019962671 abstract "Observations made in the last few years support the existence of pathways, in adult humans and rodents, that allow adult stem cells to be surprisingly flexible in their differentiation repertoires. Termed plasticity, this property allows adult stem cells, assumed, until now, to be committed to generating a fixed range of progeny, to switch, when they have been relocated, to make other specialized sets of cells appropriate to their new niche. Reprogramming of some adult stem cells can occur in vivo; the stem cells normally resident in bone marrow appear particularly flexible and are able to contribute usefully to multiple recipient organs. This process produces cells with specialized structural and metabolic adaptations commensurate with their new locations. In a few examples, the degree of support is sufficient to assist or even rescue recipient mice from genetic defects. Some studies provide evidence for the expansion of the reprogrammed cells locally, but in most it remains possible that cells arrive and redifferentiate, but are no longer stem cells. Nevertheless, the fact that appropriately differentiated cells are delivered deep within organs simply by injection of bone marrow cells should make us think differently about the way that organs regenerate and repair. Migratory pathways for stem cells in adult organisms may exist that could be exploited to effect repairs using an individual's own stem cells, perhaps after gene therapy. Logical extensions of this concept are that a transplanted organ would become affected by the genetic susceptibilities of the recipient, alleles that re-express themselves via marrow-derived stem cells, and that plasticity after bone marrow transplantation would also transfer different phenotypes, affecting important parameters such as susceptibility to long-term complications of diabetes, or the ability to metabolize drugs in the liver. This article reviews some of the evidence for stem cell plasticity in rodents and man." @default.
• W2019962671 created "2016-06-24" @default.
• W2019962671 creator A5043821826 @default.
• W2019962671 creator A5043932592 @default.
• W2019962671 creator A5070461470 @default.
• W2019962671 creator A5085100825 @default.
• W2019962671 date "2002-01-01" @default.
• W2019962671 modified "2023-10-17" @default.
• W2019962671 title "Adult stem cell plasticity" @default.
• W2019962671 cites W126539919 @default.
• W2019962671 cites W1500925969 @default.
• W2019962671 cites W1505671001 @default.
• W2019962671 cites W1507061074 @default.
• W2019962671 cites W1514351476 @default.
• W2019962671 cites W1518831632 @default.
• W2019962671 cites W1534731743 @default.
• W2019962671 cites W1542326554 @default.
• W2019962671 cites W1569560733 @default.
• W2019962671 cites W1586474677 @default.
• W2019962671 cites W1587712169 @default.
• W2019962671 cites W1590184246 @default.
• W2019962671 cites W1599090051 @default.
• W2019962671 cites W1621991227 @default.
• W2019962671 cites W1631250427 @default.
• W2019962671 cites W177057739 @default.
• W2019962671 cites W1837114049 @default.
• W2019962671 cites W1905836649 @default.
• W2019962671 cites W1964720896 @default.
• W2019962671 cites W1965190463 @default.
• W2019962671 cites W1965953554 @default.
• W2019962671 cites W1967217261 @default.
• W2019962671 cites W1968110756 @default.
• W2019962671 cites W1969662405 @default.
• W2019962671 cites W1970895440 @default.
• W2019962671 cites W1973879435 @default.
• W2019962671 cites W1974155752 @default.
• W2019962671 cites W1974359211 @default.
• W2019962671 cites W1974766733 @default.
• W2019962671 cites W1975718597 @default.
• W2019962671 cites W1976915106 @default.
• W2019962671 cites W1977592954 @default.
• W2019962671 cites W1982022033 @default.
• W2019962671 cites W1986260964 @default.
• W2019962671 cites W1986826310 @default.
• W2019962671 cites W1986912442 @default.
• W2019962671 cites W1989880720 @default.
• W2019962671 cites W1991248271 @default.
• W2019962671 cites W1991374176 @default.
• W2019962671 cites W1991415492 @default.
• W2019962671 cites W1992396018 @default.
• W2019962671 cites W1996016074 @default.
• W2019962671 cites W1997496613 @default.
• W2019962671 cites W1999579644 @default.
• W2019962671 cites W2000529657 @default.
• W2019962671 cites W2001675896 @default.
• W2019962671 cites W2002664276 @default.
• W2019962671 cites W2004421565 @default.
• W2019962671 cites W2005054221 @default.
• W2019962671 cites W2005825485 @default.
• W2019962671 cites W2005848913 @default.
• W2019962671 cites W2008491027 @default.
• W2019962671 cites W2012479859 @default.
• W2019962671 cites W2013568009 @default.
• W2019962671 cites W2016490294 @default.
• W2019962671 cites W2020684993 @default.
• W2019962671 cites W2022185139 @default.
• W2019962671 cites W2024456241 @default.
• W2019962671 cites W2025019998 @default.
• W2019962671 cites W2026637830 @default.
• W2019962671 cites W2027284829 @default.
• W2019962671 cites W2029820289 @default.
• W2019962671 cites W2035831169 @default.
• W2019962671 cites W2041232976 @default.
• W2019962671 cites W2041345380 @default.
• W2019962671 cites W2043317882 @default.
• W2019962671 cites W2044648356 @default.
• W2019962671 cites W2049318896 @default.
• W2019962671 cites W2049466721 @default.
• W2019962671 cites W2051896769 @default.
• W2019962671 cites W2052148553 @default.
• W2019962671 cites W2053704719 @default.
• W2019962671 cites W2054721944 @default.
• W2019962671 cites W2056598800 @default.
• W2019962671 cites W2059066863 @default.
• W2019962671 cites W2060139466 @default.
• W2019962671 cites W2060537844 @default.
• W2019962671 cites W2062073850 @default.
• W2019962671 cites W2062290953 @default.
• W2019962671 cites W2063379275 @default.
• W2019962671 cites W2066932246 @default.
• W2019962671 cites W2068102253 @default.
• W2019962671 cites W2070466054 @default.
• W2019962671 cites W2074070905 @default.
• W2019962671 cites W2078035943 @default.
• W2019962671 cites W2078753897 @default.
• W2019962671 cites W2080416062 @default.
• W2019962671 cites W2080546373 @default.
• W2019962671 cites W2083225096 @default.

• next