Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019964182> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2019964182 endingPage "1526" @default.
- W2019964182 startingPage "1523" @default.
- W2019964182 abstract "Under strongly basic conditions [excess LiOH, dimethoxyethane/water (4:1, vol/vol)], purified slow reacting substances (SRSs) SRS-GSH and SRS-Cys were not isomerized to their corresponding 11-trans isomers. However, addition of thiols such as glutathione (GSH) or L-cysteine to this basic medium produced various amounts of 11-trans-SRS, depending on the thiol concentration. This chemical isomerization was inhibited by the radical scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinooxy free radical (HTMP); the inhibition suggests that the thiyl radical (RS) is added reversibly to the triene system at C-12, resulting in the overall cis leads to trans isomerization of the 11,12 double bond. Because the amount of 11-trans-SRS-Cys produced by intact rat basophilic leukemia (RBL-1) cells was consistently higher than the amount produced in boiled cells, we believe that intact RBL-1 cells contain enzyme systems that form peroxides, which are known to enhance the formation of thiyl radicals, required for cis leads to trans isomerization. Likewise, HTMP inhibited the formation of 11-trans-SRS-Cys in this cell system." @default.
- W2019964182 created "2016-06-24" @default.
- W2019964182 creator A5007511291 @default.
- W2019964182 creator A5016630998 @default.
- W2019964182 creator A5050504914 @default.
- W2019964182 creator A5065126343 @default.
- W2019964182 date "1981-03-01" @default.
- W2019964182 modified "2023-09-26" @default.
- W2019964182 title "Formation of 11-trans slow reacting substances." @default.
- W2019964182 cites W1531198291 @default.
- W2019964182 cites W1981856247 @default.
- W2019964182 cites W2000232347 @default.
- W2019964182 cites W2002678045 @default.
- W2019964182 cites W2008249399 @default.
- W2019964182 cites W2011793087 @default.
- W2019964182 cites W2061482508 @default.
- W2019964182 cites W2076680940 @default.
- W2019964182 cites W2081695295 @default.
- W2019964182 cites W2123773797 @default.
- W2019964182 doi "https://doi.org/10.1073/pnas.78.3.1523" @default.
- W2019964182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/319163" @default.
- W2019964182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6112746" @default.
- W2019964182 hasPublicationYear "1981" @default.
- W2019964182 type Work @default.
- W2019964182 sameAs 2019964182 @default.
- W2019964182 citedByCount "6" @default.
- W2019964182 countsByYear W20199641822018 @default.
- W2019964182 crossrefType "journal-article" @default.
- W2019964182 hasAuthorship W2019964182A5007511291 @default.
- W2019964182 hasAuthorship W2019964182A5016630998 @default.
- W2019964182 hasAuthorship W2019964182A5050504914 @default.
- W2019964182 hasAuthorship W2019964182A5065126343 @default.
- W2019964182 hasBestOaLocation W20199641821 @default.
- W2019964182 hasConcept C126661725 @default.
- W2019964182 hasConcept C139066938 @default.
- W2019964182 hasConcept C155647269 @default.
- W2019964182 hasConcept C161790260 @default.
- W2019964182 hasConcept C181199279 @default.
- W2019964182 hasConcept C185592680 @default.
- W2019964182 hasConcept C2779201268 @default.
- W2019964182 hasConcept C2781324293 @default.
- W2019964182 hasConcept C538909803 @default.
- W2019964182 hasConcept C55493867 @default.
- W2019964182 hasConcept C56783068 @default.
- W2019964182 hasConcept C71240020 @default.
- W2019964182 hasConceptScore W2019964182C126661725 @default.
- W2019964182 hasConceptScore W2019964182C139066938 @default.
- W2019964182 hasConceptScore W2019964182C155647269 @default.
- W2019964182 hasConceptScore W2019964182C161790260 @default.
- W2019964182 hasConceptScore W2019964182C181199279 @default.
- W2019964182 hasConceptScore W2019964182C185592680 @default.
- W2019964182 hasConceptScore W2019964182C2779201268 @default.
- W2019964182 hasConceptScore W2019964182C2781324293 @default.
- W2019964182 hasConceptScore W2019964182C538909803 @default.
- W2019964182 hasConceptScore W2019964182C55493867 @default.
- W2019964182 hasConceptScore W2019964182C56783068 @default.
- W2019964182 hasConceptScore W2019964182C71240020 @default.
- W2019964182 hasIssue "3" @default.
- W2019964182 hasLocation W20199641821 @default.
- W2019964182 hasLocation W20199641822 @default.
- W2019964182 hasLocation W20199641823 @default.
- W2019964182 hasLocation W20199641824 @default.
- W2019964182 hasOpenAccess W2019964182 @default.
- W2019964182 hasPrimaryLocation W20199641821 @default.
- W2019964182 hasRelatedWork W1968537115 @default.
- W2019964182 hasRelatedWork W1983242269 @default.
- W2019964182 hasRelatedWork W1989822624 @default.
- W2019964182 hasRelatedWork W1992439512 @default.
- W2019964182 hasRelatedWork W2017138506 @default.
- W2019964182 hasRelatedWork W2023506709 @default.
- W2019964182 hasRelatedWork W2024452437 @default.
- W2019964182 hasRelatedWork W2051549153 @default.
- W2019964182 hasRelatedWork W2161426711 @default.
- W2019964182 hasRelatedWork W81342328 @default.
- W2019964182 hasVolume "78" @default.
- W2019964182 isParatext "false" @default.
- W2019964182 isRetracted "false" @default.
- W2019964182 magId "2019964182" @default.
- W2019964182 workType "article" @default.