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• W2019964232 abstract "Retinitis pigmentosa is an untreatable, inherited retinal disease that leads to blindness. The disease initiates with the loss of night vision due to rod photoreceptor degeneration, followed by irreversible, progressive loss of cone photoreceptor1,2,3. Cone loss is responsible for the main visual handicap, as cones are essential for day and high-acuity vision4. Their loss is indirect, as most genes associated with retinitis pigmentosa are not expressed by these cells. We previously showed that factors secreted from rods are essential for cone viability5,6,7,8. Here we identified one such trophic factor by expression cloning and named it rod-derived cone viability factor (RdCVF). RdCVF is a truncated thioredoxin-like protein specifically expressed by photoreceptors. The identification of this protein offers new treatment possibilities for retinitis pigmentosa." @default.
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• W2019964232 date "2004-06-27" @default.
• W2019964232 modified "2023-10-16" @default.
• W2019964232 title "Identification and characterization of rod-derived cone viability factor" @default.
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• W2019964232 doi "https://doi.org/10.1038/ng1386" @default.
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