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- W2019964376 abstract "Abstract Ultrasmall superparamagnetic iron oxide nanoparticles have been widely used during the past decade as MR intravascular contrast agents in the study of animal models. Such agents enhance both T 1 and T 2 / T 2 * relaxation, although for animal studies it is the later type of enhancement that is most commonly exploited. Their strong microscopic intravascular susceptibility effect enables the local blood volume distribution to be mapped in various organs. High spatial resolution and sensitivity can be achieved, because the long half‐life of these agents in blood, combined with anesthetization, permits steady‐state measurements over extended periods. This capability has been utilized to study the cerebrovascular blood volume distributions and their changes in normal, activated, pathologic and pharmacologically or genetically modified states, particularly in rodent animal models. It has also been applied to study blood volume changes in other tissues, such as the myocardium. The relaxation rate shifts Δ R 2 and Δ R 2 * induced by iron oxide agents may differ depending on certain morphological characteristics of the microvascular network, and sensitive Δ R 2 and Δ R 2 * mapping can potentially provide, in addition to blood volume, measurement of other important microvascular parameters such as blood vessel density and size. This work aims to review the applications of ultrasmall superparamagnetic iron oxide contrast agents in MR animal studies, with an emphasis on the investigation of microvascular parameters. Copyright © 2004 John Wiley & Sons, Ltd." @default.
- W2019964376 created "2016-06-24" @default.
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- W2019964376 date "2004-11-01" @default.
- W2019964376 modified "2023-10-16" @default.
- W2019964376 title "Applications of ultrasmall superparamagnetic iron oxide contrast agents in the MR study of animal models" @default.
- W2019964376 cites W1510613202 @default.
- W2019964376 cites W1513919882 @default.
- W2019964376 cites W1970124993 @default.
- W2019964376 cites W1972582749 @default.
- W2019964376 cites W1976983086 @default.
- W2019964376 cites W1979234968 @default.
- W2019964376 cites W1981048449 @default.
- W2019964376 cites W1983283144 @default.
- W2019964376 cites W1984338166 @default.
- W2019964376 cites W1986077698 @default.
- W2019964376 cites W1996352444 @default.
- W2019964376 cites W1997834318 @default.
- W2019964376 cites W2001992434 @default.
- W2019964376 cites W2005628251 @default.
- W2019964376 cites W2011272082 @default.
- W2019964376 cites W2016337569 @default.
- W2019964376 cites W2016524717 @default.
- W2019964376 cites W2017127142 @default.
- W2019964376 cites W2019540655 @default.
- W2019964376 cites W2020383693 @default.
- W2019964376 cites W2021975189 @default.
- W2019964376 cites W2025451175 @default.
- W2019964376 cites W2034353523 @default.
- W2019964376 cites W2035003394 @default.
- W2019964376 cites W2036116957 @default.
- W2019964376 cites W2041231560 @default.
- W2019964376 cites W2042319724 @default.
- W2019964376 cites W2046863310 @default.
- W2019964376 cites W2049046378 @default.
- W2019964376 cites W2054577434 @default.
- W2019964376 cites W2054737462 @default.
- W2019964376 cites W2055447603 @default.
- W2019964376 cites W2061571996 @default.
- W2019964376 cites W2063956554 @default.
- W2019964376 cites W2064158938 @default.
- W2019964376 cites W2064533924 @default.
- W2019964376 cites W2064906313 @default.
- W2019964376 cites W2065218488 @default.
- W2019964376 cites W2068366961 @default.
- W2019964376 cites W2069453047 @default.
- W2019964376 cites W2070396441 @default.
- W2019964376 cites W2072554608 @default.
- W2019964376 cites W2081223638 @default.
- W2019964376 cites W2082637226 @default.
- W2019964376 cites W2086171977 @default.
- W2019964376 cites W2089475586 @default.
- W2019964376 cites W2090938843 @default.
- W2019964376 cites W2091012993 @default.
- W2019964376 cites W2093449268 @default.
- W2019964376 cites W2110884735 @default.
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- W2019964376 cites W2151354541 @default.
- W2019964376 cites W2157036804 @default.
- W2019964376 cites W2160349805 @default.
- W2019964376 cites W2164324123 @default.
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- W2019964376 cites W2171882555 @default.
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- W2019964376 doi "https://doi.org/10.1002/nbm.923" @default.
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