FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019964978> ?p ?o ?g. }

• W2019964978 endingPage "1171" @default.
• W2019964978 startingPage "1160" @default.
• W2019964978 abstract "Physical association of proteins that underlies cytotoxic signal induction and transduction suggests a possibility of regulating cell response by modifying protein-protein interactions. For protein complexing, chemical cross-linking agents have been traditionally used. However, the ability of various cross-linkers to induce and modify cell responses, cell death in particular, is still obscure. We have undertaken the investigation to test the apoptosis-inducing and modifying properties of the homobifunctional cross-linkers-dimethyl suberimidate (DMS) and 1,5-bis(succinimido-oxycarbonyloxy)pentane (BSOCOP). The functional groups of these cross-linkers are different but both are able to interact with available amino groups. It was shown that bifunctional cross-linkers, unlike their monofunctional analogues, are capable of inducing cell death in transformed cells, thus indicating the crucial role of cross-linking in cell killing. DMS- and BSOCOP-treated cells were shown to undergo cell death by apoptosis, though the signaling pathways were distinct. DMS inhibited bcl-X(L) and bak but not bax gene expression, while BSOCOP potentiated bax mRNA synthesis immediately after application. Cell pre-incubation with DMS, but not with BSOCOP, resulted in an increasing sensitivity to TNF, although activities of anti-Fas cytotoxic antibodies were then inhibited. Thus, this study has demonstrated for the first time that chemical cross-linkers are capable of inducing apoptosis by themselves and modifying the TNF-dependent and Fas-mediated cell death that may have potential therapeutic significance." @default.
• W2019964978 created "2016-06-24" @default.
• W2019964978 creator A5003133591 @default.
• W2019964978 creator A5013070607 @default.
• W2019964978 creator A5020857357 @default.
• W2019964978 creator A5050895827 @default.
• W2019964978 creator A5054279340 @default.
• W2019964978 creator A5085929910 @default.
• W2019964978 date "2001-12-01" @default.
• W2019964978 modified "2023-10-08" @default.
• W2019964978 title "Cell death induced by chemical homobifunctional cross-linkers" @default.
• W2019964978 cites W1495602537 @default.
• W2019964978 cites W1562708965 @default.
• W2019964978 cites W1564214284 @default.
• W2019964978 cites W1581093018 @default.
• W2019964978 cites W1624903505 @default.
• W2019964978 cites W1644953918 @default.
• W2019964978 cites W1932879891 @default.
• W2019964978 cites W1964617786 @default.
• W2019964978 cites W1976692354 @default.
• W2019964978 cites W1979522382 @default.
• W2019964978 cites W1984696190 @default.
• W2019964978 cites W1989891990 @default.
• W2019964978 cites W1992630084 @default.
• W2019964978 cites W2002503549 @default.
• W2019964978 cites W2005091530 @default.
• W2019964978 cites W2012315366 @default.
• W2019964978 cites W2012886159 @default.
• W2019964978 cites W2015691927 @default.
• W2019964978 cites W2015988945 @default.
• W2019964978 cites W2020680466 @default.
• W2019964978 cites W2025128734 @default.
• W2019964978 cites W2032417513 @default.
• W2019964978 cites W2032514624 @default.
• W2019964978 cites W2038114873 @default.
• W2019964978 cites W2045923190 @default.
• W2019964978 cites W2055391345 @default.
• W2019964978 cites W2071055800 @default.
• W2019964978 cites W2076302307 @default.
• W2019964978 cites W2087178990 @default.
• W2019964978 cites W2088102742 @default.
• W2019964978 cites W2094334993 @default.
• W2019964978 cites W2100837269 @default.
• W2019964978 cites W2108743612 @default.
• W2019964978 cites W2114918609 @default.
• W2019964978 cites W2122458615 @default.
• W2019964978 cites W2130703400 @default.
• W2019964978 cites W2134979684 @default.
• W2019964978 cites W2140967934 @default.
• W2019964978 cites W2148304657 @default.
• W2019964978 cites W2156552404 @default.
• W2019964978 cites W2157402532 @default.
• W2019964978 cites W2261706688 @default.
• W2019964978 cites W2328407615 @default.
• W2019964978 cites W4237888277 @default.
• W2019964978 doi "https://doi.org/10.1016/s1357-2725(01)00090-5" @default.
• W2019964978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11606252" @default.
• W2019964978 hasPublicationYear "2001" @default.
• W2019964978 type Work @default.
• W2019964978 sameAs 2019964978 @default.
• W2019964978 citedByCount "5" @default.
• W2019964978 countsByYear W20199649782016 @default.
• W2019964978 countsByYear W20199649782019 @default.
• W2019964978 countsByYear W20199649782023 @default.
• W2019964978 crossrefType "journal-article" @default.
• W2019964978 hasAuthorship W2019964978A5003133591 @default.
• W2019964978 hasAuthorship W2019964978A5013070607 @default.
• W2019964978 hasAuthorship W2019964978A5020857357 @default.
• W2019964978 hasAuthorship W2019964978A5050895827 @default.
• W2019964978 hasAuthorship W2019964978A5054279340 @default.
• W2019964978 hasAuthorship W2019964978A5085929910 @default.
• W2019964978 hasConcept C1491633281 @default.
• W2019964978 hasConcept C154317977 @default.
• W2019964978 hasConcept C185592680 @default.
• W2019964978 hasConcept C190283241 @default.
• W2019964978 hasConcept C202751555 @default.
• W2019964978 hasConcept C31573885 @default.
• W2019964978 hasConcept C55493867 @default.
• W2019964978 hasConcept C62478195 @default.
• W2019964978 hasConcept C86803240 @default.
• W2019964978 hasConcept C95444343 @default.
• W2019964978 hasConceptScore W2019964978C1491633281 @default.
• W2019964978 hasConceptScore W2019964978C154317977 @default.
• W2019964978 hasConceptScore W2019964978C185592680 @default.
• W2019964978 hasConceptScore W2019964978C190283241 @default.
• W2019964978 hasConceptScore W2019964978C202751555 @default.
• W2019964978 hasConceptScore W2019964978C31573885 @default.
• W2019964978 hasConceptScore W2019964978C55493867 @default.
• W2019964978 hasConceptScore W2019964978C62478195 @default.
• W2019964978 hasConceptScore W2019964978C86803240 @default.
• W2019964978 hasConceptScore W2019964978C95444343 @default.
• W2019964978 hasFunder F4320321079 @default.
• W2019964978 hasIssue "12" @default.
• W2019964978 hasLocation W20199649781 @default.
• W2019964978 hasLocation W20199649782 @default.
• W2019964978 hasOpenAccess W2019964978 @default.
• W2019964978 hasPrimaryLocation W20199649781 @default.
• W2019964978 hasRelatedWork W1234816868 @default.

• next