Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019965522> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2019965522 endingPage "694" @default.
- W2019965522 startingPage "686" @default.
- W2019965522 abstract "Kinetics of the neuromuscular blocker d-tubocurarine (dTc) were investigated in 13 adult patients undergoing surgery involving cardiopulmonary bypass (CPB). Approximately 1 hr before CPB surgery, each received dTc as an intravenous bolus of 0.6 mg/kg and a maintenance infusion of 3 µg/kg/min. dTc plasma concentration–time data before CPB did not differ from those reported in normal surgical patients. There was an abrupt discontinuity in the plasma concentration–time profile with the onset of CPB, and both total and free plasma concentrations increased 400% during the period of CPB. Although computer simulations suggest that these rises in dTc plasma concentrations can be attributed to contraction in central compartment volume, there also was decreased renal and total plasma clearance of dTc together with a prolonged elimination t½, which suggests that clearance processes of dTc are also altered as a result of CPB. A 27% rise in dTc free fraction in plasma during CPB could be attributed to hemodilution associated with the CPB procedure itself. Lower doses of dTc will need to be used in patients undergoing surgery that involves CPB unless the concentration-effect relationship for dTc is so altered that higher concentrations are needed to elicit the same response as in normal patients. Clinical Pharmacology and Therapeutics (1984) 35, 686–694; doi:10.1038/clpt.1984.96" @default.
- W2019965522 created "2016-06-24" @default.
- W2019965522 creator A5000796136 @default.
- W2019965522 creator A5018708029 @default.
- W2019965522 creator A5084076574 @default.
- W2019965522 date "1984-05-01" @default.
- W2019965522 modified "2023-10-16" @default.
- W2019965522 title "Altered d-tubocurarine disposition during cardiopulmonary bypass surgery" @default.
- W2019965522 doi "https://doi.org/10.1038/clpt.1984.96" @default.
- W2019965522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6713781" @default.
- W2019965522 hasPublicationYear "1984" @default.
- W2019965522 type Work @default.
- W2019965522 sameAs 2019965522 @default.
- W2019965522 citedByCount "19" @default.
- W2019965522 crossrefType "journal-article" @default.
- W2019965522 hasAuthorship W2019965522A5000796136 @default.
- W2019965522 hasAuthorship W2019965522A5018708029 @default.
- W2019965522 hasAuthorship W2019965522A5084076574 @default.
- W2019965522 hasConcept C112705442 @default.
- W2019965522 hasConcept C126322002 @default.
- W2019965522 hasConcept C2778789114 @default.
- W2019965522 hasConcept C2778881276 @default.
- W2019965522 hasConcept C3020079912 @default.
- W2019965522 hasConcept C3020190219 @default.
- W2019965522 hasConcept C42219234 @default.
- W2019965522 hasConcept C43376680 @default.
- W2019965522 hasConcept C63433958 @default.
- W2019965522 hasConcept C71924100 @default.
- W2019965522 hasConcept C98274493 @default.
- W2019965522 hasConceptScore W2019965522C112705442 @default.
- W2019965522 hasConceptScore W2019965522C126322002 @default.
- W2019965522 hasConceptScore W2019965522C2778789114 @default.
- W2019965522 hasConceptScore W2019965522C2778881276 @default.
- W2019965522 hasConceptScore W2019965522C3020079912 @default.
- W2019965522 hasConceptScore W2019965522C3020190219 @default.
- W2019965522 hasConceptScore W2019965522C42219234 @default.
- W2019965522 hasConceptScore W2019965522C43376680 @default.
- W2019965522 hasConceptScore W2019965522C63433958 @default.
- W2019965522 hasConceptScore W2019965522C71924100 @default.
- W2019965522 hasConceptScore W2019965522C98274493 @default.
- W2019965522 hasIssue "5" @default.
- W2019965522 hasLocation W20199655221 @default.
- W2019965522 hasLocation W20199655222 @default.
- W2019965522 hasOpenAccess W2019965522 @default.
- W2019965522 hasPrimaryLocation W20199655221 @default.
- W2019965522 hasRelatedWork W1556115470 @default.
- W2019965522 hasRelatedWork W2005639893 @default.
- W2019965522 hasRelatedWork W2012513302 @default.
- W2019965522 hasRelatedWork W2019965522 @default.
- W2019965522 hasRelatedWork W2021313022 @default.
- W2019965522 hasRelatedWork W2031328158 @default.
- W2019965522 hasRelatedWork W2057147957 @default.
- W2019965522 hasRelatedWork W2084156393 @default.
- W2019965522 hasRelatedWork W2119318344 @default.
- W2019965522 hasRelatedWork W2156234214 @default.
- W2019965522 hasVolume "35" @default.
- W2019965522 isParatext "false" @default.
- W2019965522 isRetracted "false" @default.
- W2019965522 magId "2019965522" @default.
- W2019965522 workType "article" @default.