FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019965658> ?p ?o ?g. }

• W2019965658 endingPage "345" @default.
• W2019965658 startingPage "321" @default.
• W2019965658 abstract "We review the evidence presented in Part I showing that transcripts and protein products of maternal, gap, pair-rule, and segment polarity genes exhibit increasingly complex, multipeaked longitudinal waveforms in the early Drosophila embryo. The central problem we address in Part II is the use the embryo makes of these wave forms to specify longitudinal pattern. Based on the fact that mutants of many of these genes generate deletions and mirror symmetrical duplications of pattern elements on length scales ranging from about half the egg to within segments, we propose that position is specified by measuring a phase angle by use of the ratios of two or more variables. Pictorially, such a phase angle can be thought of as a colour on a colour wheel. Any such model contains a phaseless singularity where all or many phases, or colours, come together. We suppose as well that positional values sufficiently close to the singularity are meaningless, hence a dead zone. Duplications and deletions are accounted for by deformation of the cycle of morphogen values occurring along the antero-posterior axis. If the cycle of values surrounds the singularity and lies outside the dead zone, pattern is normal. If the curve transects the dead zone, pattern elements are deleted. If the curve lies entirely on one side of the singularity, pattern elements are deleted and others are duplicated with mirror symmetry. The existence of different wavelength transcript patterns in maternal, gap, pair-rule, and segment polarity genes and the roles of those same genes in generating deletions and mirror symmetrical duplications on a variety of length scales lead us to propose that position is measured simultaneously on at least four colour wheels, which cycle different numbers of times along the anterior-posterior axis. These yield progressively finer grained positional information. Normal pattern specification requires a unique angle, outside of the dead zone, from each of the four wheels. Deformations of the cycle of gene product concentrations yield the deletions and mirror symmetric duplications observed in the mutants discussed. The alternative familiar hypothesis that longitudinal position is specified in an on off combinatorial code does not readily account for the duplication deletion phenomena." @default.
• W2019965658 created "2016-06-24" @default.
• W2019965658 creator A5017833043 @default.
• W2019965658 creator A5079464744 @default.
• W2019965658 date "1990-06-01" @default.
• W2019965658 modified "2023-10-17" @default.
• W2019965658 title "Spatial harmonics and pattern specification in early Drosophila development. Part II. The four colour wheels model" @default.
• W2019965658 cites W1486074438 @default.
• W2019965658 cites W1966145948 @default.
• W2019965658 cites W1974988355 @default.
• W2019965658 cites W1980661496 @default.
• W2019965658 cites W1980878261 @default.
• W2019965658 cites W1985222015 @default.
• W2019965658 cites W1991725826 @default.
• W2019965658 cites W1997664026 @default.
• W2019965658 cites W2000139612 @default.
• W2019965658 cites W2000572318 @default.
• W2019965658 cites W2005906206 @default.
• W2019965658 cites W2015443629 @default.
• W2019965658 cites W2024716092 @default.
• W2019965658 cites W2031068169 @default.
• W2019965658 cites W2033186514 @default.
• W2019965658 cites W2044216868 @default.
• W2019965658 cites W2050763240 @default.
• W2019965658 cites W2057920297 @default.
• W2019965658 cites W2058632547 @default.
• W2019965658 cites W2063865276 @default.
• W2019965658 cites W2066541022 @default.
• W2019965658 cites W2067158147 @default.
• W2019965658 cites W2069462985 @default.
• W2019965658 cites W2078801028 @default.
• W2019965658 cites W2080329327 @default.
• W2019965658 cites W2086837518 @default.
• W2019965658 cites W2412928540 @default.
• W2019965658 cites W2941435896 @default.
• W2019965658 doi "https://doi.org/10.1016/s0022-5193(05)80079-7" @default.
• W2019965658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2395375" @default.
• W2019965658 hasPublicationYear "1990" @default.
• W2019965658 type Work @default.
• W2019965658 sameAs 2019965658 @default.
• W2019965658 citedByCount "9" @default.
• W2019965658 countsByYear W20199656582012 @default.
• W2019965658 countsByYear W20199656582021 @default.
• W2019965658 crossrefType "journal-article" @default.
• W2019965658 hasAuthorship W2019965658A5017833043 @default.
• W2019965658 hasAuthorship W2019965658A5079464744 @default.
• W2019965658 hasConcept C104317684 @default.
• W2019965658 hasConcept C111039654 @default.
• W2019965658 hasConcept C114614502 @default.
• W2019965658 hasConcept C121332964 @default.
• W2019965658 hasConcept C1491633281 @default.
• W2019965658 hasConcept C16171025 @default.
• W2019965658 hasConcept C165801399 @default.
• W2019965658 hasConcept C184720557 @default.
• W2019965658 hasConcept C188414643 @default.
• W2019965658 hasConcept C22251595 @default.
• W2019965658 hasConcept C2524010 @default.
• W2019965658 hasConcept C2777361361 @default.
• W2019965658 hasConcept C33923547 @default.
• W2019965658 hasConcept C54355233 @default.
• W2019965658 hasConcept C62520636 @default.
• W2019965658 hasConcept C83415579 @default.
• W2019965658 hasConcept C86339819 @default.
• W2019965658 hasConcept C86803240 @default.
• W2019965658 hasConceptScore W2019965658C104317684 @default.
• W2019965658 hasConceptScore W2019965658C111039654 @default.
• W2019965658 hasConceptScore W2019965658C114614502 @default.
• W2019965658 hasConceptScore W2019965658C121332964 @default.
• W2019965658 hasConceptScore W2019965658C1491633281 @default.
• W2019965658 hasConceptScore W2019965658C16171025 @default.
• W2019965658 hasConceptScore W2019965658C165801399 @default.
• W2019965658 hasConceptScore W2019965658C184720557 @default.
• W2019965658 hasConceptScore W2019965658C188414643 @default.
• W2019965658 hasConceptScore W2019965658C22251595 @default.
• W2019965658 hasConceptScore W2019965658C2524010 @default.
• W2019965658 hasConceptScore W2019965658C2777361361 @default.
• W2019965658 hasConceptScore W2019965658C33923547 @default.
• W2019965658 hasConceptScore W2019965658C54355233 @default.
• W2019965658 hasConceptScore W2019965658C62520636 @default.
• W2019965658 hasConceptScore W2019965658C83415579 @default.
• W2019965658 hasConceptScore W2019965658C86339819 @default.
• W2019965658 hasConceptScore W2019965658C86803240 @default.
• W2019965658 hasIssue "3" @default.
• W2019965658 hasLocation W20199656581 @default.
• W2019965658 hasLocation W20199656582 @default.
• W2019965658 hasOpenAccess W2019965658 @default.
• W2019965658 hasPrimaryLocation W20199656581 @default.
• W2019965658 hasRelatedWork W1617686442 @default.
• W2019965658 hasRelatedWork W1987865998 @default.
• W2019965658 hasRelatedWork W2019965658 @default.
• W2019965658 hasRelatedWork W2142313107 @default.
• W2019965658 hasRelatedWork W2355637465 @default.
• W2019965658 hasRelatedWork W2356140614 @default.
• W2019965658 hasRelatedWork W2373185014 @default.
• W2019965658 hasRelatedWork W3005429507 @default.
• W2019965658 hasRelatedWork W4304789908 @default.
• W2019965658 hasRelatedWork W472177835 @default.
• W2019965658 hasVolume "144" @default.

• next