Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019966198> ?p ?o ?g. }
- W2019966198 endingPage "241" @default.
- W2019966198 startingPage "231" @default.
- W2019966198 abstract "Receptor tyrosine kinases (RTKs) transduce signals via cytoplasmic adaptor proteins to downstream signaling components. We have identified loss-of-function mutations in dshc, the Drosophila homolog of the mammalian adaptor protein SHC. A point mutation in the phosphotyrosine binding (PTB) domain completely abolishes DSHC function and provides in vivo evidence for the function of PTB domains. Unlike other adaptor proteins, DSHC is involved in signaling by only a subset of RTKs: dshc mutants show defects in Torso and DER but not Sevenless signaling, which is confirmed by epistasis experiments. We show by double-mutant analysis that the adaptors DOS, DRK, and DSHC act in parallel to transduce the Torso signal. Our results suggest that DSHC confers specificity to receptor signaling." @default.
- W2019966198 created "2016-06-24" @default.
- W2019966198 creator A5037964057 @default.
- W2019966198 creator A5052066953 @default.
- W2019966198 creator A5067032967 @default.
- W2019966198 creator A5072765144 @default.
- W2019966198 creator A5080430882 @default.
- W2019966198 date "2000-02-01" @default.
- W2019966198 modified "2023-10-10" @default.
- W2019966198 title "The Drosophila SHC Adaptor Protein Is Required for Signaling by a Subset of Receptor Tyrosine Kinases" @default.
- W2019966198 cites W1772563489 @default.
- W2019966198 cites W1849498913 @default.
- W2019966198 cites W1938204331 @default.
- W2019966198 cites W1966221337 @default.
- W2019966198 cites W1967159767 @default.
- W2019966198 cites W1970396586 @default.
- W2019966198 cites W1972172786 @default.
- W2019966198 cites W1972187212 @default.
- W2019966198 cites W1974654489 @default.
- W2019966198 cites W1976410844 @default.
- W2019966198 cites W1986758681 @default.
- W2019966198 cites W1986947870 @default.
- W2019966198 cites W1987413856 @default.
- W2019966198 cites W1991765224 @default.
- W2019966198 cites W1995819749 @default.
- W2019966198 cites W2000269495 @default.
- W2019966198 cites W2002292023 @default.
- W2019966198 cites W2004543481 @default.
- W2019966198 cites W2004629227 @default.
- W2019966198 cites W2014516206 @default.
- W2019966198 cites W2015913211 @default.
- W2019966198 cites W2016049505 @default.
- W2019966198 cites W2023417672 @default.
- W2019966198 cites W2028834438 @default.
- W2019966198 cites W2029675956 @default.
- W2019966198 cites W2037196975 @default.
- W2019966198 cites W2037620887 @default.
- W2019966198 cites W2037761585 @default.
- W2019966198 cites W2043644025 @default.
- W2019966198 cites W2045095779 @default.
- W2019966198 cites W2047654571 @default.
- W2019966198 cites W2049573270 @default.
- W2019966198 cites W2051571002 @default.
- W2019966198 cites W2056257769 @default.
- W2019966198 cites W2061519657 @default.
- W2019966198 cites W2067074596 @default.
- W2019966198 cites W2073146277 @default.
- W2019966198 cites W2075957066 @default.
- W2019966198 cites W2096658690 @default.
- W2019966198 cites W2110643873 @default.
- W2019966198 cites W2116227043 @default.
- W2019966198 cites W2119937553 @default.
- W2019966198 cites W2123484521 @default.
- W2019966198 cites W2126827442 @default.
- W2019966198 cites W2130847193 @default.
- W2019966198 cites W2132246987 @default.
- W2019966198 cites W2152442542 @default.
- W2019966198 cites W2167822739 @default.
- W2019966198 cites W2170231361 @default.
- W2019966198 cites W2187192485 @default.
- W2019966198 cites W2307320799 @default.
- W2019966198 cites W77923684 @default.
- W2019966198 doi "https://doi.org/10.1016/s1097-2765(00)80419-0" @default.
- W2019966198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10882065" @default.
- W2019966198 hasPublicationYear "2000" @default.
- W2019966198 type Work @default.
- W2019966198 sameAs 2019966198 @default.
- W2019966198 citedByCount "63" @default.
- W2019966198 countsByYear W20199661982012 @default.
- W2019966198 countsByYear W20199661982013 @default.
- W2019966198 countsByYear W20199661982017 @default.
- W2019966198 countsByYear W20199661982019 @default.
- W2019966198 countsByYear W20199661982022 @default.
- W2019966198 crossrefType "journal-article" @default.
- W2019966198 hasAuthorship W2019966198A5037964057 @default.
- W2019966198 hasAuthorship W2019966198A5052066953 @default.
- W2019966198 hasAuthorship W2019966198A5067032967 @default.
- W2019966198 hasAuthorship W2019966198A5072765144 @default.
- W2019966198 hasAuthorship W2019966198A5080430882 @default.
- W2019966198 hasBestOaLocation W20199661981 @default.
- W2019966198 hasConcept C101544691 @default.
- W2019966198 hasConcept C104317684 @default.
- W2019966198 hasConcept C143065580 @default.
- W2019966198 hasConcept C170493617 @default.
- W2019966198 hasConcept C183786373 @default.
- W2019966198 hasConcept C196347352 @default.
- W2019966198 hasConcept C2911166042 @default.
- W2019966198 hasConcept C54355233 @default.
- W2019966198 hasConcept C62478195 @default.
- W2019966198 hasConcept C86803240 @default.
- W2019966198 hasConcept C95444343 @default.
- W2019966198 hasConceptScore W2019966198C101544691 @default.
- W2019966198 hasConceptScore W2019966198C104317684 @default.
- W2019966198 hasConceptScore W2019966198C143065580 @default.
- W2019966198 hasConceptScore W2019966198C170493617 @default.
- W2019966198 hasConceptScore W2019966198C183786373 @default.
- W2019966198 hasConceptScore W2019966198C196347352 @default.
- W2019966198 hasConceptScore W2019966198C2911166042 @default.