Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019966403> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2019966403 endingPage "340" @default.
- W2019966403 startingPage "337" @default.
- W2019966403 abstract "For large-scale synthesis of monocalcium bis[(2S)-2-benzyl-3-(cis-hexahydroisoindolin-2-ylcarbonyl)propionate]dihydrate (1, KAD-1229), we investigated regioselective reactions of (S)-2-benzylsuccinic acid (2) with cis-hexahydroisoindoline (4). It was difficult to obtain a half amide regioselectively through coupling reaction of the (S)-acid 2 with the amine 4. Therefore, the succinic acid 2 was converted to bis-activated esters 3a-c and these were reacted with 4 to give the amides 5a-c in good yields, regioselectively. The amides 5a-c were derived to KAD-1229, which has a potent hypoglycemic effect, in good yields." @default.
- W2019966403 created "2016-06-24" @default.
- W2019966403 creator A5021394220 @default.
- W2019966403 creator A5030315039 @default.
- W2019966403 creator A5032187153 @default.
- W2019966403 creator A5039373673 @default.
- W2019966403 creator A5046048026 @default.
- W2019966403 creator A5076716208 @default.
- W2019966403 date "1998-01-01" @default.
- W2019966403 modified "2023-10-15" @default.
- W2019966403 title "Preparation of Optically Active Succinic Acid Derivatives. II. Efficient and Practical Synthesis of KAD-1229." @default.
- W2019966403 doi "https://doi.org/10.1248/cpb.46.337" @default.
- W2019966403 hasPublicationYear "1998" @default.
- W2019966403 type Work @default.
- W2019966403 sameAs 2019966403 @default.
- W2019966403 citedByCount "12" @default.
- W2019966403 countsByYear W20199664032014 @default.
- W2019966403 countsByYear W20199664032017 @default.
- W2019966403 countsByYear W20199664032018 @default.
- W2019966403 crossrefType "journal-article" @default.
- W2019966403 hasAuthorship W2019966403A5021394220 @default.
- W2019966403 hasAuthorship W2019966403A5030315039 @default.
- W2019966403 hasAuthorship W2019966403A5032187153 @default.
- W2019966403 hasAuthorship W2019966403A5039373673 @default.
- W2019966403 hasAuthorship W2019966403A5046048026 @default.
- W2019966403 hasAuthorship W2019966403A5076716208 @default.
- W2019966403 hasBestOaLocation W20199664031 @default.
- W2019966403 hasConcept C131779359 @default.
- W2019966403 hasConcept C155647269 @default.
- W2019966403 hasConcept C161790260 @default.
- W2019966403 hasConcept C178790620 @default.
- W2019966403 hasConcept C185592680 @default.
- W2019966403 hasConcept C2778439535 @default.
- W2019966403 hasConcept C2780014933 @default.
- W2019966403 hasConcept C2781041046 @default.
- W2019966403 hasConcept C59759590 @default.
- W2019966403 hasConceptScore W2019966403C131779359 @default.
- W2019966403 hasConceptScore W2019966403C155647269 @default.
- W2019966403 hasConceptScore W2019966403C161790260 @default.
- W2019966403 hasConceptScore W2019966403C178790620 @default.
- W2019966403 hasConceptScore W2019966403C185592680 @default.
- W2019966403 hasConceptScore W2019966403C2778439535 @default.
- W2019966403 hasConceptScore W2019966403C2780014933 @default.
- W2019966403 hasConceptScore W2019966403C2781041046 @default.
- W2019966403 hasConceptScore W2019966403C59759590 @default.
- W2019966403 hasIssue "2" @default.
- W2019966403 hasLocation W20199664031 @default.
- W2019966403 hasOpenAccess W2019966403 @default.
- W2019966403 hasPrimaryLocation W20199664031 @default.
- W2019966403 hasRelatedWork W2010006047 @default.
- W2019966403 hasRelatedWork W2042011280 @default.
- W2019966403 hasRelatedWork W2059203659 @default.
- W2019966403 hasRelatedWork W2106450890 @default.
- W2019966403 hasRelatedWork W2765221321 @default.
- W2019966403 hasRelatedWork W2946783333 @default.
- W2019966403 hasRelatedWork W2951239537 @default.
- W2019966403 hasRelatedWork W2951539138 @default.
- W2019966403 hasRelatedWork W2953245046 @default.
- W2019966403 hasRelatedWork W3060712741 @default.
- W2019966403 hasVolume "46" @default.
- W2019966403 isParatext "false" @default.
- W2019966403 isRetracted "false" @default.
- W2019966403 magId "2019966403" @default.
- W2019966403 workType "article" @default.