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- W2019966616 abstract "The cytotoxic activities of human blood mononuclear cells against certain established cell lines were evaluated prospectively in 17 patients with rheumatoid arthritis before and after treatment with low (150 mg per week) and moderate doses (300 mg per week) of levamisole. Spontaneous or natural killer activity (NK) and antibody-dependent cellular cytotoxicity (ADCC) of plastic adherent cells (monocytes) and lymphocytes were studied. We report a selective cytotoxic defect in monocyte NK and a correlation of this defect with severely active disease. The patients with the most severe defect responded to low-dose levamisole, but others with normal values did nor respond as well to treatment. This cytotoxic defect may be an important pathogenetic factor in rheumatoid arthritis and this new assay may be helpful in selecting candidates who are most likely to respond to levamisole." @default.
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- W2019966616 date "1982-01-01" @default.
- W2019966616 modified "2023-09-27" @default.
- W2019966616 title "Defective monocyte cytotoxicity in rheumatoid arthritis" @default.
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- W2019966616 doi "https://doi.org/10.1002/art.1780250102" @default.
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