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• W2019967317 abstract "β-Glucogallin (BGG), a major component of the Emblica officinalis medicinal plant, is a potent and selective inhibitor of aldose reductase (AKR1B1). New linkages (ether/triazole/amide) were introduced via high yielding, efficient syntheses to replace the labile ester, and an original two-step (90%) preparation of BGG was developed. Inhibition of AKR1B1was assessed in vitro and using transgenic lens organ cultures, which identified the amide linked glucoside (BGA) as a stable, potent, and selective therapeutic lead toward the treatment of diabetic eye disease." @default.
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• W2019967317 date "2013-12-23" @default.
• W2019967317 modified "2023-09-26" @default.
• W2019967317 title "Design of an Amide <i>N</i>-Glycoside Derivative of β-Glucogallin: A Stable, Potent, and Specific Inhibitor of Aldose Reductase" @default.
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• W2019967317 doi "https://doi.org/10.1021/jm401311d" @default.
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