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- W2019967851 abstract "Arodyn (aromatic dynorphin) is a novel analogue of the opioid peptide dynorphin A with a nonbasic N-terminus that exhibits nanomolar affinity (K(i) = 10 nM) and remarkable selectivity for kappa opioid receptors (K(i) ratio (kappa/mu/delta) = 1/174/583). Arodyn completely reverses the agonism of dynorphin A (1-13)NH(2) in a concentration-dependent manner in the adenylyl cyclase assay. Thus arodyn is a novel kappa opioid receptor selective antagonist that will be useful to study these receptors." @default.
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- W2019967851 date "2002-11-22" @default.
- W2019967851 modified "2023-09-29" @default.
- W2019967851 title "Identification of Arodyn, a Novel Acetylated Dynorphin A-(1−11) Analogue, as a κ Opioid Receptor Antagonist" @default.
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- W2019967851 doi "https://doi.org/10.1021/jm025575g" @default.
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