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• W2019967936 abstract "Inhibitory effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the proliferation of a variety of cancer cell lines have been extensively reported. We have studied the effect of 1,25-(OH)2D3 (10(-11)-10(-6) M) on the proliferation of a number of human and rat liver cancer cell lines. Additionally, the effect of 1,25-(OH)2D3 (0.02-0.5 microg/kg per day) on the rate of growth of liver cancer cell line xenografts in nude mice was also investigated. In vitro, proliferation of Hep-3B, PLC/PRF/5, and SKHEP-1 cells was significantly inhibited by 1,25-(OH)2D3, while HTC and Novikoff cells were more resistant to the inhibitory effects of the drug. In vivo, treatment of SKHEP-1 tumor bearing nude mice with different doses of 1,25-(OH)2D3 significantly retarded tumor growth without the development of hypercalcemia." @default.
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• W2019967936 date "2000-04-01" @default.
• W2019967936 modified "2023-09-24" @default.
• W2019967936 title "In vitro and in vivo inhibition of liver cancer cells by 1,25-dihydroxyvitamin D3" @default.
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• W2019967936 doi "https://doi.org/10.1016/s0304-3835(99)00416-4" @default.
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