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• W2019968234 abstract "Cochrane reviews are viewed as the gold standard in meta-analyses given their efforts to identify and limit systematic error which could cause spurious conclusions. The potential for random error to cause spurious conclusions in meta-analyses is less well appreciated.We examined all reviews approved and published by the Cochrane Heart Group in the 2012 Cochrane Library that included at least one meta-analysis with 5 or more randomized trials. We used trial sequential analysis to classify statistically significant meta-analyses as true positives if their pooled sample size and/or their cumulative Z-curve crossed the O'Brien-Fleming monitoring boundaries for detecting a RRR of at least 25%. We classified meta-analyses that did not achieve statistical significance as true negatives if their pooled sample size was sufficient to reject a RRR of 25%.Twenty three (41%) of the 56 meta-analyses reported statistically significant results, and 19 (83%) were true positives. Of the 33 non-statistically significant meta-analyses, 12 (36%) were true negatives. Overall, 25 (45%) of the 56 published Cochrane reviews were too small to detect/rule out an effect size of at least 25% - 12 were acknowledged as such by their authors. Of the 22 meta-analyses which were reported to be conclusive by their authors, 12 (55%) contained insufficient data to detect/rule out a 25% relative treatment effect.False positive and false negative meta-analyses are common but infrequently recognized, even among methodologically robust reviews published by the Cochrane Heart Group. Meta-analysts and readers should incorporate trial sequential analysis when interpreting results." @default.
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• W2019968234 date "2013-09-01" @default.
• W2019968234 modified "2023-10-14" @default.
• W2019968234 title "Random error in cardiovascular meta-analyses: How common are false positive and false negative results?" @default.
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• W2019968234 doi "https://doi.org/10.1016/j.ijcard.2012.11.048" @default.
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