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- W2019968368 abstract "Frailty is a clinically recognised syndrome of decreased physiological reserve. The heightened state of vulnerability in these patients confers a greater risk of adverse outcomes and affects recovery from even minor stressors. Frailty has yet to be characterised in a cohort of heart transplantation listed patients. All patients referred or on the waiting list for a heart transplantation between March 2013 and July 2014 underwent a frailty assessment. Frailty was defined as three or more and of the following components; weak grip strength, slowed walking speed, poor appetite, physical inactivity and exhaustion. In addition, markers of disease severity were obtained and all patients underwent cognitive (Montreal Cognitive Assessment, MOCA) and depressive (Depression in Medical Illness, DMI) screening. 102 patients (70M:32F; age 53 + 14 years, range 20-73; LVEF 26 + 13%) underwent frailty assessment; 79 patients (78%) had some degree of frailty: 32 patients (31%) were classified as frail and 47 (46%) were pre-frail. Frailty was associated with being female, anaemia, hypoalbuminaemia, and increased levels of bilirubin. Frailty was independent of age, renal function, cognitive impairment or being depressed. Kaplan-Meier cumulative survival curves identified frailty as being significantly associated with increased mortality: follow-up survival was ~70%, ~75% and ~47% for non-frail, pre-frail and frail patients respectively (figure). Frailty is highly prevalent among patients listed for heart transplantation. There exists a strong potential for frailty assessment to independently risk-stratify patients with advanced heart failure." @default.
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- W2019968368 date "2015-04-01" @default.
- W2019968368 modified "2023-09-27" @default.
- W2019968368 title "Frailty as a Predictor of Outcomes in Heart Transplant-Eligible Patients With Advanced Heart Failure" @default.
- W2019968368 doi "https://doi.org/10.1016/j.healun.2015.01.512" @default.
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