Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019968377> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2019968377 endingPage "61" @default.
- W2019968377 startingPage "57" @default.
- W2019968377 abstract "The kinetics and pathways for degradation of (+/-)-4'-ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone hydrochloride (HY-770; 1), a newly developed muscle-relaxing agent, and its analogues were studied in aqueous solution at 50 degrees C, ionic strength 0.5 M, and pH 8.0-12.0. Compound 1 and its four analogues followed pseudo-first-order degradation kinetics at constant pH and temperature. From the analysis of the pH degradation-rate profiles, it is evident that specific hydroxide ion-catalyzed degradations of ionized and un-ionized species occur for 1 and its structural analogue, 3'-fluoro-2-methyl-3-(1-pyrrolidinyl)propiophenone hydrochloride (HN-961; 5). The hydroxide ion-catalyzed degradation of the ionized species was found to be 100 times faster than that of the un-ionized species and to be the major process at pH less than 9.0. On the contrary, 1 was extremely stable in 0.5 M HCl at 50 degrees C, suggesting that the hydronium ion-catalyzed degradation and the spontaneous degradation of the ionized species is negligible. The Arrhenius plot for the degradation of 1 at 35-50 degrees C and pH 9.0 showed that the apparent energy of activation was 22.0 kcal/mol. The degradation rates of the five structural analogues were significantly dependent on the electron withdrawing effect of the benzene substituents of the molecule." @default.
- W2019968377 created "2016-06-24" @default.
- W2019968377 creator A5003023435 @default.
- W2019968377 creator A5019755982 @default.
- W2019968377 creator A5026158271 @default.
- W2019968377 creator A5026770912 @default.
- W2019968377 creator A5053910262 @default.
- W2019968377 creator A5067834903 @default.
- W2019968377 date "1989-01-01" @default.
- W2019968377 modified "2023-09-25" @default.
- W2019968377 title "Degradation Kinetics of (±)-4′-Ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone Hydrochloride (HY-770) and Structure–Stability Relationship among its Analogues in Aqueous Solution" @default.
- W2019968377 cites W2020952440 @default.
- W2019968377 cites W2024191422 @default.
- W2019968377 cites W2321271784 @default.
- W2019968377 doi "https://doi.org/10.1002/jps.2600780115" @default.
- W2019968377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2709320" @default.
- W2019968377 hasPublicationYear "1989" @default.
- W2019968377 type Work @default.
- W2019968377 sameAs 2019968377 @default.
- W2019968377 citedByCount "2" @default.
- W2019968377 crossrefType "journal-article" @default.
- W2019968377 hasAuthorship W2019968377A5003023435 @default.
- W2019968377 hasAuthorship W2019968377A5019755982 @default.
- W2019968377 hasAuthorship W2019968377A5026158271 @default.
- W2019968377 hasAuthorship W2019968377A5026770912 @default.
- W2019968377 hasAuthorship W2019968377A5053910262 @default.
- W2019968377 hasAuthorship W2019968377A5067834903 @default.
- W2019968377 hasConcept C121332964 @default.
- W2019968377 hasConcept C13965031 @default.
- W2019968377 hasConcept C148898269 @default.
- W2019968377 hasConcept C161790260 @default.
- W2019968377 hasConcept C178790620 @default.
- W2019968377 hasConcept C179104552 @default.
- W2019968377 hasConcept C184651966 @default.
- W2019968377 hasConcept C185592680 @default.
- W2019968377 hasConcept C2775896084 @default.
- W2019968377 hasConcept C2776460385 @default.
- W2019968377 hasConcept C2779679103 @default.
- W2019968377 hasConcept C41008148 @default.
- W2019968377 hasConcept C62520636 @default.
- W2019968377 hasConcept C76155785 @default.
- W2019968377 hasConcept C8739425 @default.
- W2019968377 hasConcept C93391505 @default.
- W2019968377 hasConcept C95121573 @default.
- W2019968377 hasConceptScore W2019968377C121332964 @default.
- W2019968377 hasConceptScore W2019968377C13965031 @default.
- W2019968377 hasConceptScore W2019968377C148898269 @default.
- W2019968377 hasConceptScore W2019968377C161790260 @default.
- W2019968377 hasConceptScore W2019968377C178790620 @default.
- W2019968377 hasConceptScore W2019968377C179104552 @default.
- W2019968377 hasConceptScore W2019968377C184651966 @default.
- W2019968377 hasConceptScore W2019968377C185592680 @default.
- W2019968377 hasConceptScore W2019968377C2775896084 @default.
- W2019968377 hasConceptScore W2019968377C2776460385 @default.
- W2019968377 hasConceptScore W2019968377C2779679103 @default.
- W2019968377 hasConceptScore W2019968377C41008148 @default.
- W2019968377 hasConceptScore W2019968377C62520636 @default.
- W2019968377 hasConceptScore W2019968377C76155785 @default.
- W2019968377 hasConceptScore W2019968377C8739425 @default.
- W2019968377 hasConceptScore W2019968377C93391505 @default.
- W2019968377 hasConceptScore W2019968377C95121573 @default.
- W2019968377 hasIssue "1" @default.
- W2019968377 hasLocation W20199683771 @default.
- W2019968377 hasLocation W20199683772 @default.
- W2019968377 hasOpenAccess W2019968377 @default.
- W2019968377 hasPrimaryLocation W20199683771 @default.
- W2019968377 hasRelatedWork W1987331503 @default.
- W2019968377 hasRelatedWork W1997716552 @default.
- W2019968377 hasRelatedWork W2023846072 @default.
- W2019968377 hasRelatedWork W2038643416 @default.
- W2019968377 hasRelatedWork W2040146024 @default.
- W2019968377 hasRelatedWork W2052472050 @default.
- W2019968377 hasRelatedWork W2079054572 @default.
- W2019968377 hasRelatedWork W2273453297 @default.
- W2019968377 hasRelatedWork W2292918249 @default.
- W2019968377 hasRelatedWork W2391351724 @default.
- W2019968377 hasVolume "78" @default.
- W2019968377 isParatext "false" @default.
- W2019968377 isRetracted "false" @default.
- W2019968377 magId "2019968377" @default.
- W2019968377 workType "article" @default.