Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019968555> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2019968555 endingPage "1006" @default.
- W2019968555 startingPage "1001" @default.
- W2019968555 abstract "Mice and rats were treated, during different stages of pregnancy, with 6-azauridine (AzUR), an inhibitor of pyrimidine synthesis de novo. Pregnancy and the effects of AzUR were observed and confirmed at the time of laparotomy, and gross and histological studies were performed on the products of conception. AzUR, given in doses of 2–4 g/kg to mice and of 4–6 g/kg to rats, was highly embryotoxic primarily during the period from day 5 to day 10 of pregnancy; subsequent to embryonic deaths, the necrotic embryos and placentas were resorbed in utero. When AzUR was administered before day 4, embryotoxicity was not observed, while after day 10 exposure to the drug often resulted in the premature delivery of either sick or dead progeny. The high toxicity of AzUR between day 5 and day 10 of pregnancy suggests that, during this phase of embryogenesis, certain tissues of the developing organism are critically dependent upon the biosynthesis of pyrimidines de novo. It is postulated that, during the first half of pregnancy the biosynthesis of pyrimidines is blocked by AzUR, except when the drug cannot reach the implanted ovum via the maternal blood stream, i.e. prior to implantation and during the very early stage of implantation. During the second half of pregnancy, it is suggested that the fetuses are probably not totally dependent upon the availability of pyrimidines formed de novo; nevertheless, effects of AzUR are still encountered, because adequate doses of it may cause either the premature delivery of fetuses with decreased viability or the expulsion of dead fetuses." @default.
- W2019968555 created "2016-06-24" @default.
- W2019968555 creator A5036816486 @default.
- W2019968555 creator A5069814251 @default.
- W2019968555 date "1970-03-01" @default.
- W2019968555 modified "2023-09-23" @default.
- W2019968555 title "The mode of interruption of pregnancy by 6-azauridine in mice and rats" @default.
- W2019968555 cites W1489320421 @default.
- W2019968555 cites W1969623367 @default.
- W2019968555 cites W1991147821 @default.
- W2019968555 cites W1996666502 @default.
- W2019968555 cites W2017095143 @default.
- W2019968555 cites W2338397715 @default.
- W2019968555 doi "https://doi.org/10.1016/0006-2952(70)90363-1" @default.
- W2019968555 hasPublicationYear "1970" @default.
- W2019968555 type Work @default.
- W2019968555 sameAs 2019968555 @default.
- W2019968555 citedByCount "3" @default.
- W2019968555 crossrefType "journal-article" @default.
- W2019968555 hasAuthorship W2019968555A5036816486 @default.
- W2019968555 hasAuthorship W2019968555A5069814251 @default.
- W2019968555 hasConcept C126322002 @default.
- W2019968555 hasConcept C134018914 @default.
- W2019968555 hasConcept C16685009 @default.
- W2019968555 hasConcept C172680121 @default.
- W2019968555 hasConcept C196843134 @default.
- W2019968555 hasConcept C201614185 @default.
- W2019968555 hasConcept C2779234561 @default.
- W2019968555 hasConcept C29730261 @default.
- W2019968555 hasConcept C42407357 @default.
- W2019968555 hasConcept C54355233 @default.
- W2019968555 hasConcept C65290608 @default.
- W2019968555 hasConcept C71924100 @default.
- W2019968555 hasConcept C86803240 @default.
- W2019968555 hasConcept C95444343 @default.
- W2019968555 hasConceptScore W2019968555C126322002 @default.
- W2019968555 hasConceptScore W2019968555C134018914 @default.
- W2019968555 hasConceptScore W2019968555C16685009 @default.
- W2019968555 hasConceptScore W2019968555C172680121 @default.
- W2019968555 hasConceptScore W2019968555C196843134 @default.
- W2019968555 hasConceptScore W2019968555C201614185 @default.
- W2019968555 hasConceptScore W2019968555C2779234561 @default.
- W2019968555 hasConceptScore W2019968555C29730261 @default.
- W2019968555 hasConceptScore W2019968555C42407357 @default.
- W2019968555 hasConceptScore W2019968555C54355233 @default.
- W2019968555 hasConceptScore W2019968555C65290608 @default.
- W2019968555 hasConceptScore W2019968555C71924100 @default.
- W2019968555 hasConceptScore W2019968555C86803240 @default.
- W2019968555 hasConceptScore W2019968555C95444343 @default.
- W2019968555 hasLocation W20199685551 @default.
- W2019968555 hasOpenAccess W2019968555 @default.
- W2019968555 hasPrimaryLocation W20199685551 @default.
- W2019968555 hasRelatedWork W1993795923 @default.
- W2019968555 hasRelatedWork W1996920188 @default.
- W2019968555 hasRelatedWork W2002562299 @default.
- W2019968555 hasRelatedWork W2022187101 @default.
- W2019968555 hasRelatedWork W2091151050 @default.
- W2019968555 hasRelatedWork W2096397790 @default.
- W2019968555 hasRelatedWork W2131811784 @default.
- W2019968555 hasRelatedWork W2141521254 @default.
- W2019968555 hasRelatedWork W3023069117 @default.
- W2019968555 hasRelatedWork W2156499933 @default.
- W2019968555 hasVolume "19" @default.
- W2019968555 isParatext "false" @default.
- W2019968555 isRetracted "false" @default.
- W2019968555 magId "2019968555" @default.
- W2019968555 workType "article" @default.