Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019969295> ?p ?o ?g. }
- W2019969295 endingPage "14718" @default.
- W2019969295 startingPage "14708" @default.
- W2019969295 abstract "Huntington's disease (HD) is caused by an expansion of the polyglutamine tract at the N terminus of huntingtin. This mutation reduces levels of BDNF in the striatum, likely by inhibiting cortical Bdnf gene expression and anterograde transport of BDNF from the cerebral cortex to the striatum. Substantial evidence suggests that this reduction of striatal BDNF plays a crucial role in HD pathogenesis. Here we report that overexpression of BDNF in the forebrain rescues many disease phenotypes in YAC128 mice that express a full-length human huntingtin mutant with a 128-glutamine tract. The Bdnf transgene, under the control of the promoter for α subunit of Ca(2+)/calmodulin-dependent protein kinase II, greatly increased BDNF levels in the cerebral cortex and striatum. BDNF overexpression in YAC128 mice prevented loss and atrophy of striatal neurons and motor dysfunction, normalized expression of the striatal dopamine receptor D2 and enkephalin, and improved procedural learning. Furthermore, quantitative analyses of Golgi-impregnated neurons revealed a decreased spine density and abnormal spine morphology in striatal neurons of YAC128 mice, which was also reversed by increasing BDNF levels in the striatum. These results demonstrate that reduced striatal BDNF plays a crucial role in the HD pathogenesis and suggest that attempts to restore striatal BDNF level may have therapeutic effects to the disease." @default.
- W2019969295 created "2016-06-24" @default.
- W2019969295 creator A5035599351 @default.
- W2019969295 creator A5036256254 @default.
- W2019969295 creator A5047722409 @default.
- W2019969295 date "2010-11-03" @default.
- W2019969295 modified "2023-10-17" @default.
- W2019969295 title "BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice" @default.
- W2019969295 cites W1496088120 @default.
- W2019969295 cites W1572665175 @default.
- W2019969295 cites W1872989146 @default.
- W2019969295 cites W1905860502 @default.
- W2019969295 cites W1941550741 @default.
- W2019969295 cites W1969634414 @default.
- W2019969295 cites W1973827313 @default.
- W2019969295 cites W1977569817 @default.
- W2019969295 cites W1983080743 @default.
- W2019969295 cites W1983465753 @default.
- W2019969295 cites W1984444180 @default.
- W2019969295 cites W1989921507 @default.
- W2019969295 cites W1991506806 @default.
- W2019969295 cites W1993068285 @default.
- W2019969295 cites W1999869114 @default.
- W2019969295 cites W2000434144 @default.
- W2019969295 cites W2015241097 @default.
- W2019969295 cites W2017394604 @default.
- W2019969295 cites W2021228443 @default.
- W2019969295 cites W2021541944 @default.
- W2019969295 cites W2026124745 @default.
- W2019969295 cites W2040409885 @default.
- W2019969295 cites W2040671431 @default.
- W2019969295 cites W2042716629 @default.
- W2019969295 cites W2047636024 @default.
- W2019969295 cites W2051556001 @default.
- W2019969295 cites W2062102056 @default.
- W2019969295 cites W2062682951 @default.
- W2019969295 cites W2065544304 @default.
- W2019969295 cites W2066386560 @default.
- W2019969295 cites W2068113532 @default.
- W2019969295 cites W2071776514 @default.
- W2019969295 cites W2073485320 @default.
- W2019969295 cites W2077305976 @default.
- W2019969295 cites W2080118783 @default.
- W2019969295 cites W2082334789 @default.
- W2019969295 cites W2082592533 @default.
- W2019969295 cites W2086528223 @default.
- W2019969295 cites W2093320992 @default.
- W2019969295 cites W2095099413 @default.
- W2019969295 cites W2103350456 @default.
- W2019969295 cites W2115807468 @default.
- W2019969295 cites W2125105780 @default.
- W2019969295 cites W2131545168 @default.
- W2019969295 cites W2135306800 @default.
- W2019969295 cites W2145674449 @default.
- W2019969295 cites W2146267270 @default.
- W2019969295 cites W2149858533 @default.
- W2019969295 cites W2154409965 @default.
- W2019969295 cites W2157226283 @default.
- W2019969295 cites W2158437989 @default.
- W2019969295 cites W2162407586 @default.
- W2019969295 cites W2163208059 @default.
- W2019969295 cites W2165909414 @default.
- W2019969295 cites W2168583567 @default.
- W2019969295 cites W2170256902 @default.
- W2019969295 cites W4206144694 @default.
- W2019969295 cites W4243114653 @default.
- W2019969295 doi "https://doi.org/10.1523/jneurosci.1637-10.2010" @default.
- W2019969295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2989389" @default.
- W2019969295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21048129" @default.
- W2019969295 hasPublicationYear "2010" @default.
- W2019969295 type Work @default.
- W2019969295 sameAs 2019969295 @default.
- W2019969295 citedByCount "210" @default.
- W2019969295 countsByYear W20199692952012 @default.
- W2019969295 countsByYear W20199692952013 @default.
- W2019969295 countsByYear W20199692952014 @default.
- W2019969295 countsByYear W20199692952015 @default.
- W2019969295 countsByYear W20199692952016 @default.
- W2019969295 countsByYear W20199692952017 @default.
- W2019969295 countsByYear W20199692952018 @default.
- W2019969295 countsByYear W20199692952019 @default.
- W2019969295 countsByYear W20199692952020 @default.
- W2019969295 countsByYear W20199692952021 @default.
- W2019969295 countsByYear W20199692952022 @default.
- W2019969295 countsByYear W20199692952023 @default.
- W2019969295 crossrefType "journal-article" @default.
- W2019969295 hasAuthorship W2019969295A5035599351 @default.
- W2019969295 hasAuthorship W2019969295A5036256254 @default.
- W2019969295 hasAuthorship W2019969295A5047722409 @default.
- W2019969295 hasBestOaLocation W20199692951 @default.
- W2019969295 hasConcept C126322002 @default.
- W2019969295 hasConcept C134018914 @default.
- W2019969295 hasConcept C169760540 @default.
- W2019969295 hasConcept C2777616661 @default.
- W2019969295 hasConcept C2779134260 @default.
- W2019969295 hasConcept C2779715522 @default.
- W2019969295 hasConcept C2780062018 @default.
- W2019969295 hasConcept C2780647506 @default.