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- W2019969899 abstract "Persistent viral infections are a major health concern. One obstacle inhibiting the clearance of persistent infections is functional inactivation of antiviral T cells. Although such immunosuppression occurs rapidly after infection, the mechanisms that induce the loss of T-cell activity and promote viral persistence are unknown. Herein we document that persistent viral infection in mice results in a significant upregulation of interleukin (IL)-10 by antigen-presenting cells, leading to impaired T-cell responses. Genetic removal of Il10 resulted in the maintenance of robust effector T-cell responses, the rapid elimination of virus and the development of antiviral memory T-cell responses. Therapeutic administration of an antibody that blocks the IL-10 receptor restored T-cell function and eliminated viral infection. Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence." @default.
- W2019969899 created "2016-06-24" @default.
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- W2019969899 date "2006-10-15" @default.
- W2019969899 modified "2023-10-01" @default.
- W2019969899 title "Interleukin-10 determines viral clearance or persistence in vivo" @default.
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- W2019969899 doi "https://doi.org/10.1038/nm1492" @default.
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