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• W2019970473 abstract "Background Hemoglobin-based blood substitutes may cause vasoconstriction, which could limit organ perfusion during trauma resuscitation. We investigated the effect of two hemoglobin solutions on regional blood flow and mucosal perfusion in the gastrointestinal tract in a hemorrhagic shock model. Methods Twenty-four swine were bled 30% of blood volume over 1 hour. Six additional animals were anesthetized and monitored but did not undergo hemorrhage. Bled animals were resuscitated with alpha alpha-hemoglobin (alpha alpha Hb), pyridoxalated hemoglobin polyoxyethylene conjugate (PHP), shed blood, or lactated Ringer's solution. Regional blood flow was measured by radiolabeled microspheres. Gastric mucosal perfusion was estimated by measuring intramucosal pH (pHi) by tonometry. Results PHP and shed blood restored small-bowel flows to sham values, whereas lactated Ringer's solution and alpha alpha Hb did not. Shed blood and PHP, but not alpha alpha Hb, restored cardiac index (CI) to baseline (p < 0.05). Mean pulmonary artery pressure was elevated over baseline with alpha alpha Hb and PHP and remained elevated with alpha alpha Hb (p < 0.05). pHi was significantly lower after resuscitation with PHP than with other fluids. Conclusion PHP was efficacious in restoring CI and small-bowel flow, but the pHi remained low, indicating possible continued mucosal ischemia. alpha alpha Hb led to limited recovery of CI and small-bowel blood flow but restored pHi close to baseline. Shed blood was efficacious in restoration of pHi, gastrointestinal blood flows, and systemic hemodynamics." @default.
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• W2019970473 date "1998-09-01" @default.
• W2019970473 modified "2023-10-18" @default.
• W2019970473 title "Effect of alpha alpha-Cross-Linked Hemoglobin and Pyridoxalated Hemoglobin Polyoxyethylene Conjugate Solutions on Gastrointestinal Regional Perfusion in Hemorrhagic Shock" @default.
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• W2019970473 doi "https://doi.org/10.1097/00005373-199809000-00006" @default.
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