FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019970974> ?p ?o ?g. }

• W2019970974 abstract "Abstract Evidence for sperm-borne proteolytic enzymes exposed during the acrosome reaction in sea urchin sperm has been accumulating. To investigate the possible role(s) such enzymes have in fertilization, we studied the effects of several protease inhibitors on sperm-related events. Soybean trypsin inhibitor, Nα-p-tosyl- l -lysine, chloromethyl ketone, phenylmethylsulfonyl fluoride, and chymostatin neither reduced the number of acrosome reactions nor interfered with gamete binding. p-Nitrophenyl-p′-guanidinobenzoate caused sperm to fuse into irregular clumps, rendering them unable to fertilize eggs. However, l -1-tosylamide-2-phenylethyl chloromethyl ketone (TPCK), an inhibitor of chymotrypsin, prevented the acrosome reaction in Strongylocentrotus purpuratus, S. droebachiensis, and Lytechinus pictus. The effects of TPCK on sperm in subsequent steps of fertilization were also investigated. First, gamete binding assays were performed on fixed eggs. This precluded any effects TPCK might have had on egg-derived secretions (e.g., proteases). Binding of prereacted sperm occurred with both fixed and living eggs. However, fertilization of living eggs in the presence of TPCK was greatly reduced, even though sperm had been prereacted with egg jelly. Vitelline coats were then removed from eggs by trypsin treatment. Eggs in TPCK fertilized and developed normally after the above treatment. These observations are consistent with the hypothesis of a sperm protease participating in the acrosome reaction and the penetration of the egg vitelline coat in the sea urchin." @default.
• W2019970974 created "2016-06-24" @default.
• W2019970974 creator A5042328891 @default.
• W2019970974 creator A5042539362 @default.
• W2019970974 date "1982-09-01" @default.
• W2019970974 modified "2023-09-27" @default.
• W2019970974 title "Effects of protease inhibitors on sperm-related events in sea urchin fertilization" @default.
• W2019970974 cites W1480896717 @default.
• W2019970974 cites W1506440892 @default.
• W2019970974 cites W1512925792 @default.
• W2019970974 cites W1545367100 @default.
• W2019970974 cites W1588308265 @default.
• W2019970974 cites W1973991332 @default.
• W2019970974 cites W2003385096 @default.
• W2019970974 cites W2004506740 @default.
• W2019970974 cites W2007279313 @default.
• W2019970974 cites W2011652112 @default.
• W2019970974 cites W2011807735 @default.
• W2019970974 cites W2020993495 @default.
• W2019970974 cites W2030082109 @default.
• W2019970974 cites W2047615096 @default.
• W2019970974 cites W2051973371 @default.
• W2019970974 cites W2059685114 @default.
• W2019970974 cites W2060613245 @default.
• W2019970974 cites W2066458435 @default.
• W2019970974 cites W2070588340 @default.
• W2019970974 cites W2075391559 @default.
• W2019970974 cites W2078831549 @default.
• W2019970974 cites W2094662626 @default.
• W2019970974 cites W2157498705 @default.
• W2019970974 cites W2268838032 @default.
• W2019970974 cites W2301187126 @default.
• W2019970974 doi "https://doi.org/10.1016/0012-1606(82)90247-0" @default.
• W2019970974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6889997" @default.
• W2019970974 hasPublicationYear "1982" @default.
• W2019970974 type Work @default.
• W2019970974 sameAs 2019970974 @default.
• W2019970974 citedByCount "27" @default.
• W2019970974 countsByYear W20199709742014 @default.
• W2019970974 crossrefType "journal-article" @default.
• W2019970974 hasAuthorship W2019970974A5042328891 @default.
• W2019970974 hasAuthorship W2019970974A5042539362 @default.
• W2019970974 hasConcept C105702510 @default.
• W2019970974 hasConcept C113835550 @default.
• W2019970974 hasConcept C141814087 @default.
• W2019970974 hasConcept C16685009 @default.
• W2019970974 hasConcept C181199279 @default.
• W2019970974 hasConcept C182220744 @default.
• W2019970974 hasConcept C196843134 @default.
• W2019970974 hasConcept C2776690073 @default.
• W2019970974 hasConcept C2776714187 @default.
• W2019970974 hasConcept C2776803348 @default.
• W2019970974 hasConcept C2776908312 @default.
• W2019970974 hasConcept C2778252442 @default.
• W2019970974 hasConcept C2779995066 @default.
• W2019970974 hasConcept C2781087480 @default.
• W2019970974 hasConcept C55493867 @default.
• W2019970974 hasConcept C59822182 @default.
• W2019970974 hasConcept C71924100 @default.
• W2019970974 hasConcept C86803240 @default.
• W2019970974 hasConcept C88972607 @default.
• W2019970974 hasConcept C90642696 @default.
• W2019970974 hasConcept C95444343 @default.
• W2019970974 hasConceptScore W2019970974C105702510 @default.
• W2019970974 hasConceptScore W2019970974C113835550 @default.
• W2019970974 hasConceptScore W2019970974C141814087 @default.
• W2019970974 hasConceptScore W2019970974C16685009 @default.
• W2019970974 hasConceptScore W2019970974C181199279 @default.
• W2019970974 hasConceptScore W2019970974C182220744 @default.
• W2019970974 hasConceptScore W2019970974C196843134 @default.
• W2019970974 hasConceptScore W2019970974C2776690073 @default.
• W2019970974 hasConceptScore W2019970974C2776714187 @default.
• W2019970974 hasConceptScore W2019970974C2776803348 @default.
• W2019970974 hasConceptScore W2019970974C2776908312 @default.
• W2019970974 hasConceptScore W2019970974C2778252442 @default.
• W2019970974 hasConceptScore W2019970974C2779995066 @default.
• W2019970974 hasConceptScore W2019970974C2781087480 @default.
• W2019970974 hasConceptScore W2019970974C55493867 @default.
• W2019970974 hasConceptScore W2019970974C59822182 @default.
• W2019970974 hasConceptScore W2019970974C71924100 @default.
• W2019970974 hasConceptScore W2019970974C86803240 @default.
• W2019970974 hasConceptScore W2019970974C88972607 @default.
• W2019970974 hasConceptScore W2019970974C90642696 @default.
• W2019970974 hasConceptScore W2019970974C95444343 @default.
• W2019970974 hasLocation W20199709741 @default.
• W2019970974 hasLocation W20199709742 @default.
• W2019970974 hasOpenAccess W2019970974 @default.
• W2019970974 hasPrimaryLocation W20199709741 @default.
• W2019970974 hasRelatedWork W1558221932 @default.
• W2019970974 hasRelatedWork W2015482740 @default.
• W2019970974 hasRelatedWork W2019970974 @default.
• W2019970974 hasRelatedWork W2049986832 @default.
• W2019970974 hasRelatedWork W2053262409 @default.
• W2019970974 hasRelatedWork W2054577200 @default.
• W2019970974 hasRelatedWork W2070331288 @default.
• W2019970974 hasRelatedWork W2070588340 @default.
• W2019970974 hasRelatedWork W2085184724 @default.
• W2019970974 hasRelatedWork W2144533388 @default.
• W2019970974 isParatext "false" @default.
• W2019970974 isRetracted "false" @default.

• next