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- W2019973807 abstract "Insulin resistance plays a central role in the development of the metabolic syndrome, but how it relates to cardiovascular disease remains controversial. Liver insulin receptor knockout (LIRKO) mice have pure hepatic insulin resistance. On a standard chow diet, LIRKO mice have a proatherogenic lipoprotein profile with reduced high-density lipoprotein (HDL) cholesterol and very low-density lipoprotein (VLDL) particles that are markedly enriched in cholesterol. This is due to increased secretion and decreased clearance of apolipoprotein B-containing lipoproteins, coupled with decreased triglyceride secretion secondary to increased expression of Pgc-1 beta (Ppargc-1b), which promotes VLDL secretion, but decreased expression of Srebp-1c (Srebf1), Srebp-2 (Srebf2), and their targets, the lipogenic enzymes and the LDL receptor. Within 12 weeks on an atherogenic diet, LIRKO mice show marked hypercholesterolemia, and 100% of LIRKO mice, but 0% of controls, develop severe atherosclerosis. Thus, insulin resistance at the level of the liver is sufficient to produce the dyslipidemia and increased risk of atherosclerosis associated with the metabolic syndrome." @default.
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- W2019973807 date "2008-02-01" @default.
- W2019973807 modified "2023-10-18" @default.
- W2019973807 title "Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis" @default.
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- W2019973807 cites W1978476677 @default.
- W2019973807 cites W1982489657 @default.
- W2019973807 cites W1986349550 @default.
- W2019973807 cites W1986519087 @default.
- W2019973807 cites W1990805315 @default.
- W2019973807 cites W1991735443 @default.
- W2019973807 cites W2001901848 @default.
- W2019973807 cites W2005430088 @default.
- W2019973807 cites W2009033372 @default.
- W2019973807 cites W2009306260 @default.
- W2019973807 cites W2016291847 @default.
- W2019973807 cites W2022543078 @default.
- W2019973807 cites W2023662872 @default.
- W2019973807 cites W2024851295 @default.
- W2019973807 cites W2030610610 @default.
- W2019973807 cites W2032731208 @default.
- W2019973807 cites W2036812212 @default.
- W2019973807 cites W2039250890 @default.
- W2019973807 cites W2039999119 @default.
- W2019973807 cites W2047046963 @default.
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- W2019973807 cites W2049878977 @default.
- W2019973807 cites W2051870109 @default.
- W2019973807 cites W2054239245 @default.
- W2019973807 cites W2056245899 @default.
- W2019973807 cites W2060968396 @default.
- W2019973807 cites W2061864595 @default.
- W2019973807 cites W2063086702 @default.
- W2019973807 cites W2072036731 @default.
- W2019973807 cites W2073625229 @default.
- W2019973807 cites W2080528312 @default.
- W2019973807 cites W2084273795 @default.
- W2019973807 cites W2095500795 @default.
- W2019973807 cites W2096773810 @default.
- W2019973807 cites W2102785858 @default.
- W2019973807 cites W2111895850 @default.
- W2019973807 cites W2115621633 @default.
- W2019973807 cites W2119390770 @default.
- W2019973807 cites W2120852510 @default.
- W2019973807 cites W2120862552 @default.
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- W2019973807 cites W2131553564 @default.
- W2019973807 cites W2134292324 @default.
- W2019973807 cites W2135536111 @default.
- W2019973807 cites W2136629006 @default.
- W2019973807 cites W2137591316 @default.
- W2019973807 cites W2141823673 @default.
- W2019973807 cites W2142156174 @default.
- W2019973807 cites W2142263097 @default.
- W2019973807 cites W2146109620 @default.
- W2019973807 cites W2153661281 @default.
- W2019973807 cites W2155391879 @default.
- W2019973807 cites W2157817725 @default.
- W2019973807 cites W2166961959 @default.
- W2019973807 cites W2167130513 @default.
- W2019973807 cites W2168724512 @default.
- W2019973807 cites W2171290692 @default.
- W2019973807 cites W2187391773 @default.
- W2019973807 cites W2313099710 @default.
- W2019973807 cites W2331274940 @default.
- W2019973807 cites W4231624455 @default.
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- W2019973807 doi "https://doi.org/10.1016/j.cmet.2007.11.013" @default.
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