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- W2019974362 abstract "Lymphocytopenia (LP) is common in patients with acute myocardial infarction (AMI). In addition the incidence of hypertension (HTN) is higher in Blacks and Hispanics than white. Our purpose was to study the effects of LP and HTN on mortality in the patients with AMI in an inner city hospital. We conducted a restropective chart review of 206 consecutive patients admitted with AMI in an inner city hospital serving mostly Black, and Hispanics of diverse nationality. An automated CBC drawn at the time of admission was reviewed for lymphocyte %. LP was defined as lymphocyte % < 20. Patients (N = 40) with comorbid conditions such as fulminant infection, septicemia or acute surgical conditions that can cause LP were excluded. History of hypertension and/or on antihypertensive treatment made up the HTN group, others made up the NHTN group. The effect of HTN and LP on mortality was examined separately and in combination. Out of 166 patients 65 were Blacks 93 were Hispanics and 78 were females. LP was present in 58% of all patients and it occurred with same frequency in Blacks, Hispanics, HTN, NHTN as well as both genders. Overall 67% of patients had HTN and it occurred with same frequency in Blacks, Hispanics, both genders, diabetics, smokers. HTN were older compared to NHTN (mean age 68 Vs 59, P = 0.001). On an univariate analysis, both HTN (P = 0.03) and LP (P = 0.01) were significant predictors of mortality (9 of 166). However, on both stratified analysis and multivariate logistic regression analysis only those patients with both HTN and LP were at significant risk of mortality compared with those who had only one or none of these risk factors. Other factors (i.e.: age, sex, race, smoking, hypercholesterolemia, diabetes, HOMI, Q MI, peak CPK) were not independent predictors of mortality. Among the excluded patients although the mortality rate was higher (73%), there was no association between HTN/LP combination and death. In an inner city hospital population in patients with AMI, LP and HTN is common. Among all the factors included in the multivariate analysis only interaction between HTN and LP was significant predictors of mortality. This was an unexpected finding and the mechanism of this interaction in not understood." @default.
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- W2019974362 date "2000-06-01" @default.
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- W2019974362 title "Combination of hypertension and relative lymphocytopenia predicts mortality in patients with acute myocardial infarction in an inner city hospital" @default.
- W2019974362 doi "https://doi.org/10.1016/s0895-7061(00)00832-3" @default.
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