FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019974695> ?p ?o ?g. }

• W2019974695 endingPage "90" @default.
• W2019974695 startingPage "82" @default.
• W2019974695 abstract "Background The mechanisms underlying heart failure induced by adriamycin are very complicated and still unclear. The aim of this study was to investigate whether autophagy was involved in the progression of heart failure induced by adriamycin, so that we can develop a novel treatment strategy for heart failure. Methods 3-methyladenine (3MA), a specific inhibitor on autophagy was used in a heart failure model of rats induced by adriamycin. Neonatal cardiomyocytes were isolated from Sprague–Dawley rat hearts and randomly divided into controls, an adriamycin-treated group, and a 3MA plus adriamycin-treated group. We then examined the morphology, expression of beclin 1 gene, mitochondrial permeability transition (MPT), and Na+–K+ ATPase activity in vivo. We also assessed cell viability, mitochondrial membrane potential changes and counted autophagic vacuoles in cultured cardiomyocytes. In addition, we analyzed the expression of autophagy associated gene, beclin 1 using RT-PCR and Western blotting in an animal model. Results 3MA significantly improved cardiac function and reduced mitochondrial injury. Furthermore, adriamycin induced the formation of autophagic vacuoles, and 3MA strongly downregulated the expression of beclin 1 in adriamycin-induced failing heart and inhibited the formation of autophagic vacuoles. Conclusion Autophagic cardiomyocyte death plays an important role in the pathogenesis of heart failure in rats induced by adriamycin. Mitochondrial injury may be involved in the progression of heart failure caused by adriamycin via the autophagy pathway." @default.
• W2019974695 created "2016-06-24" @default.
• W2019974695 creator A5022000477 @default.
• W2019974695 creator A5041934647 @default.
• W2019974695 creator A5062627778 @default.
• W2019974695 creator A5074845558 @default.
• W2019974695 creator A5079940252 @default.
• W2019974695 creator A5083729859 @default.
• W2019974695 date "2009-05-01" @default.
• W2019974695 modified "2023-09-30" @default.
• W2019974695 title "Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure" @default.
• W2019974695 cites W1593406565 @default.
• W2019974695 cites W1968192793 @default.
• W2019974695 cites W1973472942 @default.
• W2019974695 cites W1976062999 @default.
• W2019974695 cites W1998988408 @default.
• W2019974695 cites W2003079927 @default.
• W2019974695 cites W2010559308 @default.
• W2019974695 cites W2011166211 @default.
• W2019974695 cites W2014814344 @default.
• W2019974695 cites W2017855147 @default.
• W2019974695 cites W2024050471 @default.
• W2019974695 cites W2024511566 @default.
• W2019974695 cites W2027082110 @default.
• W2019974695 cites W2069838096 @default.
• W2019974695 cites W2071221374 @default.
• W2019974695 cites W2073297014 @default.
• W2019974695 cites W2079327708 @default.
• W2019974695 cites W2082796078 @default.
• W2019974695 cites W2087920955 @default.
• W2019974695 cites W2092566326 @default.
• W2019974695 cites W2108086395 @default.
• W2019974695 cites W2115886998 @default.
• W2019974695 cites W2128694891 @default.
• W2019974695 cites W2131089732 @default.
• W2019974695 cites W2144687501 @default.
• W2019974695 cites W2145206598 @default.
• W2019974695 cites W2151582019 @default.
• W2019974695 cites W2151766741 @default.
• W2019974695 cites W2162843846 @default.
• W2019974695 doi "https://doi.org/10.1016/j.ijcard.2008.01.043" @default.
• W2019974695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18619688" @default.
• W2019974695 hasPublicationYear "2009" @default.
• W2019974695 type Work @default.
• W2019974695 sameAs 2019974695 @default.
• W2019974695 citedByCount "153" @default.
• W2019974695 countsByYear W20199746952012 @default.
• W2019974695 countsByYear W20199746952013 @default.
• W2019974695 countsByYear W20199746952014 @default.
• W2019974695 countsByYear W20199746952015 @default.
• W2019974695 countsByYear W20199746952016 @default.
• W2019974695 countsByYear W20199746952017 @default.
• W2019974695 countsByYear W20199746952018 @default.
• W2019974695 countsByYear W20199746952019 @default.
• W2019974695 countsByYear W20199746952020 @default.
• W2019974695 countsByYear W20199746952021 @default.
• W2019974695 countsByYear W20199746952022 @default.
• W2019974695 countsByYear W20199746952023 @default.
• W2019974695 crossrefType "journal-article" @default.
• W2019974695 hasAuthorship W2019974695A5022000477 @default.
• W2019974695 hasAuthorship W2019974695A5041934647 @default.
• W2019974695 hasAuthorship W2019974695A5062627778 @default.
• W2019974695 hasAuthorship W2019974695A5074845558 @default.
• W2019974695 hasAuthorship W2019974695A5079940252 @default.
• W2019974695 hasAuthorship W2019974695A5083729859 @default.
• W2019974695 hasConcept C102568950 @default.
• W2019974695 hasConcept C126322002 @default.
• W2019974695 hasConcept C1491633281 @default.
• W2019974695 hasConcept C150903083 @default.
• W2019974695 hasConcept C190062978 @default.
• W2019974695 hasConcept C190283241 @default.
• W2019974695 hasConcept C203522944 @default.
• W2019974695 hasConcept C207001950 @default.
• W2019974695 hasConcept C207200792 @default.
• W2019974695 hasConcept C2778198053 @default.
• W2019974695 hasConcept C28859421 @default.
• W2019974695 hasConcept C31573885 @default.
• W2019974695 hasConcept C53227056 @default.
• W2019974695 hasConcept C55493867 @default.
• W2019974695 hasConcept C71924100 @default.
• W2019974695 hasConcept C86803240 @default.
• W2019974695 hasConcept C95444343 @default.
• W2019974695 hasConcept C98274493 @default.
• W2019974695 hasConceptScore W2019974695C102568950 @default.
• W2019974695 hasConceptScore W2019974695C126322002 @default.
• W2019974695 hasConceptScore W2019974695C1491633281 @default.
• W2019974695 hasConceptScore W2019974695C150903083 @default.
• W2019974695 hasConceptScore W2019974695C190062978 @default.
• W2019974695 hasConceptScore W2019974695C190283241 @default.
• W2019974695 hasConceptScore W2019974695C203522944 @default.
• W2019974695 hasConceptScore W2019974695C207001950 @default.
• W2019974695 hasConceptScore W2019974695C207200792 @default.
• W2019974695 hasConceptScore W2019974695C2778198053 @default.
• W2019974695 hasConceptScore W2019974695C28859421 @default.
• W2019974695 hasConceptScore W2019974695C31573885 @default.
• W2019974695 hasConceptScore W2019974695C53227056 @default.
• W2019974695 hasConceptScore W2019974695C55493867 @default.
• W2019974695 hasConceptScore W2019974695C71924100 @default.

• next