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• W2019976528 abstract "A novel approach to synthesize chitosan–O-isopropyl-5′-O-d4T monophosphate conjugate was developed. Chitosan-d4T monophosphate prodrug with a phosphoramidate linkage was efficiently synthesized through Atherton-Todd reaction. In vitro drug release studies in pH 1.1 and 7.4 indicated that chitosan–O-isopropyl-5′-O-d4T monophosphate conjugate prefers to release the d4T 5′-(O-isopropyl)monophosphate than free d4T for a prolonged period. The results suggested that chitosan–O-isopropyl-5′-O-d4T monophosphate conjugate may be used as a sustained polymeric prodrug for improving therapy efficacy and reducing side effects in antiretroviral treatment." @default.
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• W2019976528 date "2009-05-01" @default.
• W2019976528 modified "2023-10-16" @default.
• W2019976528 title "Novel synthesis and in vitro drug release of polymeric prodrug: Chitosan–O-isopropyl-5′-O-d4T monophosphate conjugate" @default.
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• W2019976528 doi "https://doi.org/10.1016/j.bmcl.2009.03.044" @default.
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