Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019977271> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2019977271 endingPage "341" @default.
- W2019977271 startingPage "333" @default.
- W2019977271 abstract "The aim of this study was to examine the therapeutic efficacy of 177Lu-DOTA-Re(Arg11)CCMSH in the B16/F1 murine melanoma-bearing mouse model. Methods:177Lu-DOTA-Re(Arg11)CCMSH was prepared in 0.5 M NH4OAc at a pH of 5.4. Two (2) treatment groups of 10 melanoma-bearing C57 mice were administrated with 2 × 18.5 MBq and 1 × 37.0 MBq of 177Lu-DOTA-Re(Arg11)CCMSH through the tail vein, respectively. One (1) group of 10 melanoma-bearing C57 mice was injected with saline placebos as untreated melanoma-bearing controls. Results: In contrast to the untreated melanomabearing control group, 177Lu-DOTA-Re(Arg11)CCMSH administration yielded rapid and lasting ther-apeutic effects in the treatment groups. 177Lu-DOTA-Re(Arg11)CCMSH treatment decreased the tumor growth rate and significantly (p < 0.05) prolonged the survival time of melanoma-bearing C57 mice. Treatment with 2 × 18.5 MBq or 1 × 37.0 MBq of 177Lu-DOTA-Re(Arg11)CCMSH significantly extended the mean survival of tumor-bearing mice from 13.3 to 15.1 and 16.2 days, respectively. 177Lu-DOTA-Re(Arg11)CCMSH treatment produced no observed acute renal toxicity. Conclusions: The therapy study results revealed that 177Lu-DOTA-Re(Arg11)CCMSH yielded quantitative therapeutic effects in B16/F1 melanoma-bearing mice and appeared to be a promising radiolabeled peptide for the targeted radionuclide therapy of melanoma." @default.
- W2019977271 created "2016-06-24" @default.
- W2019977271 creator A5001152143 @default.
- W2019977271 creator A5020280965 @default.
- W2019977271 creator A5039431211 @default.
- W2019977271 date "2007-06-01" @default.
- W2019977271 modified "2023-10-02" @default.
- W2019977271 title "Therapeutic Efficacy of a <sup>177</sup>Lu-Labeled DOTA Conjugated <i>α</i>-Melanocyte-Stimulating Hormone Peptide in a Murine Melanoma-Bearing Mouse Model" @default.
- W2019977271 cites W1496673861 @default.
- W2019977271 cites W1951046932 @default.
- W2019977271 cites W1963592300 @default.
- W2019977271 cites W1970716955 @default.
- W2019977271 cites W1973069842 @default.
- W2019977271 cites W1974440984 @default.
- W2019977271 cites W1982055976 @default.
- W2019977271 cites W1984882652 @default.
- W2019977271 cites W1996018952 @default.
- W2019977271 cites W1997017520 @default.
- W2019977271 cites W2000515830 @default.
- W2019977271 cites W2012600554 @default.
- W2019977271 cites W2015546047 @default.
- W2019977271 cites W2040471046 @default.
- W2019977271 cites W2058245862 @default.
- W2019977271 cites W2065594133 @default.
- W2019977271 cites W2091939318 @default.
- W2019977271 cites W2099564842 @default.
- W2019977271 cites W2124496566 @default.
- W2019977271 cites W2131043862 @default.
- W2019977271 cites W2133962195 @default.
- W2019977271 cites W2148246811 @default.
- W2019977271 cites W2169983485 @default.
- W2019977271 cites W4234199246 @default.
- W2019977271 doi "https://doi.org/10.1089/cbr.2007.376.a" @default.
- W2019977271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17651039" @default.
- W2019977271 hasPublicationYear "2007" @default.
- W2019977271 type Work @default.
- W2019977271 sameAs 2019977271 @default.
- W2019977271 citedByCount "26" @default.
- W2019977271 countsByYear W20199772712012 @default.
- W2019977271 countsByYear W20199772712013 @default.
- W2019977271 countsByYear W20199772712016 @default.
- W2019977271 countsByYear W20199772712017 @default.
- W2019977271 countsByYear W20199772712018 @default.
- W2019977271 countsByYear W20199772712019 @default.
- W2019977271 countsByYear W20199772712020 @default.
- W2019977271 countsByYear W20199772712021 @default.
- W2019977271 countsByYear W20199772712022 @default.
- W2019977271 crossrefType "journal-article" @default.
- W2019977271 hasAuthorship W2019977271A5001152143 @default.
- W2019977271 hasAuthorship W2019977271A5020280965 @default.
- W2019977271 hasAuthorship W2019977271A5039431211 @default.
- W2019977271 hasConcept C102652120 @default.
- W2019977271 hasConcept C126322002 @default.
- W2019977271 hasConcept C150903083 @default.
- W2019977271 hasConcept C207001950 @default.
- W2019977271 hasConcept C2777658100 @default.
- W2019977271 hasConcept C2779931791 @default.
- W2019977271 hasConcept C2993559085 @default.
- W2019977271 hasConcept C502942594 @default.
- W2019977271 hasConcept C71924100 @default.
- W2019977271 hasConcept C86803240 @default.
- W2019977271 hasConceptScore W2019977271C102652120 @default.
- W2019977271 hasConceptScore W2019977271C126322002 @default.
- W2019977271 hasConceptScore W2019977271C150903083 @default.
- W2019977271 hasConceptScore W2019977271C207001950 @default.
- W2019977271 hasConceptScore W2019977271C2777658100 @default.
- W2019977271 hasConceptScore W2019977271C2779931791 @default.
- W2019977271 hasConceptScore W2019977271C2993559085 @default.
- W2019977271 hasConceptScore W2019977271C502942594 @default.
- W2019977271 hasConceptScore W2019977271C71924100 @default.
- W2019977271 hasConceptScore W2019977271C86803240 @default.
- W2019977271 hasIssue "3" @default.
- W2019977271 hasLocation W20199772711 @default.
- W2019977271 hasLocation W20199772712 @default.
- W2019977271 hasOpenAccess W2019977271 @default.
- W2019977271 hasPrimaryLocation W20199772711 @default.
- W2019977271 hasRelatedWork W169615067 @default.
- W2019977271 hasRelatedWork W2004283758 @default.
- W2019977271 hasRelatedWork W2007213983 @default.
- W2019977271 hasRelatedWork W2021968456 @default.
- W2019977271 hasRelatedWork W2047019936 @default.
- W2019977271 hasRelatedWork W2068861579 @default.
- W2019977271 hasRelatedWork W2412245334 @default.
- W2019977271 hasRelatedWork W2981372661 @default.
- W2019977271 hasRelatedWork W3161723263 @default.
- W2019977271 hasRelatedWork W72023491 @default.
- W2019977271 hasVolume "22" @default.
- W2019977271 isParatext "false" @default.
- W2019977271 isRetracted "false" @default.
- W2019977271 magId "2019977271" @default.
- W2019977271 workType "article" @default.