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• W2019977484 abstract "Aims . The aim of this study was to evaluate the effect of acute glycemia increase on microvasculature and endothelium in Type 1 diabetes during hyperinsulinemic clamp. Patients and Methods . Sixteen patients (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>51</mml:mn><mml:mo>±</mml:mo><mml:mn>7</mml:mn></mml:mrow></mml:math> yrs) without complications were examined during iso- and hyperglycemic clamp (glucose increase 5.5 mmol⋅L −1 ). Insulin, lipid parameters, cell adhesion molecules and fibrinogen were analyzed. Microvascular reactivity (MVR) was measured by laser Doppler flowmetry. Results . Maximum perfusion and the velocity of perfusion increase during PORH were higher in hyperglycemia compared to baseline (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>47</mml:mn><mml:mo>±</mml:mo><mml:mn>16</mml:mn></mml:mrow></mml:math>versus<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>40</mml:mn><mml:mo>±</mml:mo><mml:mn>16</mml:mn></mml:mrow></mml:math> PU,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.01</mml:mn></mml:mrow></mml:math>, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>10.4</mml:mn><mml:mo>±</mml:mo><mml:mn>16.5</mml:mn></mml:mrow></mml:math>versus<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>2.6</mml:mn><mml:mo>±</mml:mo><mml:mn>1.5</mml:mn></mml:mrow></mml:math> PU⋅s −1 ,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>, resp.). Time to the maximum perfusion during TH was shorter and velocity of perfusion increase during TH higher at hyperglycemia compared to isoglycemic phase (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>69</mml:mn><mml:mo>±</mml:mo><mml:mn>15</mml:mn></mml:mrow></mml:math>versus<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>77</mml:mn><mml:mo>±</mml:mo><mml:mn>16</mml:mn></mml:mrow></mml:math> s,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>1.4</mml:mn><mml:mo>±</mml:mo><mml:mn>0.8</mml:mn></mml:mrow></mml:math>versus<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>1.2</mml:mn><mml:mo>±</mml:mo><mml:mn>0.7</mml:mn></mml:mrow></mml:math> PU⋅s −1 ,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.05</mml:mn></mml:mrow></mml:math>, resp.). An inverse relationship was found between insulinemia and the time to maximum perfusion during PORH (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mo>−</mml:mo><mml:mn>0.70</mml:mn></mml:mrow></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.007</mml:mn></mml:mrow></mml:math>). Conclusion . Acute glycemia did not impair microvascular reactivity in this clamp study in Type 1 diabetic patients. Our results suggest that insulin may play a significant role in the regulation of microvascular perfusion in patients with Type 1 diabetes through its vasodilation effect and can counteract the effect of acute glucose fluctuations." @default.
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• W2019977484 date "2012-01-01" @default.
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• W2019977484 title "Acute Hyperglycemia Does Not Impair Microvascular Reactivity and Endothelial Function during Hyperinsulinemic Isoglycemic and Hyperglycemic Clamp in Type 1 Diabetic Patients" @default.
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• W2019977484 doi "https://doi.org/10.1155/2012/851487" @default.
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