FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019977717> ?p ?o ?g. }

• W2019977717 endingPage "432" @default.
• W2019977717 startingPage "422" @default.
• W2019977717 abstract "Clinically, a large number of patients have persistent low back pain attributable to intervertebral disc (IVD) degeneration. After the concept of biologically regenerating the degenerated IVD using growth factor injection was first proposed in early 1990, the advancement of molecular technology to produce recombinant proteins, including growth factors, on an industrial scale accelerated research in this field. The purpose of this review is to summarize the most recent findings of the in vitro and in vivo effects of growth factors on the IVD and, further, to discuss the limitations of growth factor therapy and its clinical implications. In vitro data showed that stimulation of matrix synthesis by growth factors alters the balance of homeostasis by shifting cellular metabolism to the anabolic state. In vivo data using small animals has shown the possibility of using growth factors as a “structural modifying therapy”. Based on in vitro and in vivo data previously reported, the clinical application of growth factors by direct injection of protein into the nucleus pulposus or anulus fibrosus was shown to be feasible as a new therapeutic intervention for treatment of disc degeneration. Stimulation of the biological repair process will create a new category of therapy to treat disc degeneration, where no active treatment currently exists, between conservative therapies and more aggressive therapies such as fusion or disc replacement. However, it should be noted that there are several important factors to be taken into consideration. In a relatively advanced degenerative condition, the supply of nutrients is disturbed and stimulation of cellular activity by growth factors may result in an increased demand for nutrients, eventually inducing an adverse event. Further investigations of the optimal environment for growth factor stimulation should be pursued. Growth factor therapy, which has experimental evidence supporting it to be a “structural modifying therapy”, may not be a “symptom modifying therapy” that is able to resolve the symptoms associated with pathologic changes. Therefore, further studies on the effect of growth factor therapy on pain are essential to shed light on its therapeutic usefulness for degenerative disc disease." @default.
• W2019977717 created "2016-06-24" @default.
• W2019977717 creator A5000662848 @default.
• W2019977717 creator A5069437689 @default.
• W2019977717 date "2006-07-25" @default.
• W2019977717 modified "2023-09-25" @default.
• W2019977717 title "Prevention of disc degeneration with growth factors" @default.
• W2019977717 cites W1453797714 @default.
• W2019977717 cites W1495436755 @default.
• W2019977717 cites W1505597474 @default.
• W2019977717 cites W1533220576 @default.
• W2019977717 cites W1581461985 @default.
• W2019977717 cites W1964178830 @default.
• W2019977717 cites W1964315433 @default.
• W2019977717 cites W1965282660 @default.
• W2019977717 cites W1966782529 @default.
• W2019977717 cites W1967613174 @default.
• W2019977717 cites W1968742787 @default.
• W2019977717 cites W1970093515 @default.
• W2019977717 cites W1973847681 @default.
• W2019977717 cites W1974624312 @default.
• W2019977717 cites W1979233208 @default.
• W2019977717 cites W1980095106 @default.
• W2019977717 cites W1980791701 @default.
• W2019977717 cites W1988821487 @default.
• W2019977717 cites W1992123733 @default.
• W2019977717 cites W1994834259 @default.
• W2019977717 cites W1995869085 @default.
• W2019977717 cites W1996917356 @default.
• W2019977717 cites W2004001363 @default.
• W2019977717 cites W2004232044 @default.
• W2019977717 cites W2011961608 @default.
• W2019977717 cites W2018559769 @default.
• W2019977717 cites W2019275635 @default.
• W2019977717 cites W2019386666 @default.
• W2019977717 cites W2020381981 @default.
• W2019977717 cites W2021449823 @default.
• W2019977717 cites W2021454273 @default.
• W2019977717 cites W2024585159 @default.
• W2019977717 cites W2024883410 @default.
• W2019977717 cites W2035709886 @default.
• W2019977717 cites W2036264639 @default.
• W2019977717 cites W2036586548 @default.
• W2019977717 cites W2037767922 @default.
• W2019977717 cites W2040834574 @default.
• W2019977717 cites W2041077761 @default.
• W2019977717 cites W2041689053 @default.
• W2019977717 cites W2044196034 @default.
• W2019977717 cites W2044434797 @default.
• W2019977717 cites W2045115929 @default.
• W2019977717 cites W2047128284 @default.
• W2019977717 cites W2051970129 @default.
• W2019977717 cites W2053173623 @default.
• W2019977717 cites W2056732606 @default.
• W2019977717 cites W2062712136 @default.
• W2019977717 cites W2064563396 @default.
• W2019977717 cites W2064700294 @default.
• W2019977717 cites W2065580273 @default.
• W2019977717 cites W2066797969 @default.
• W2019977717 cites W2067140883 @default.
• W2019977717 cites W2068560230 @default.
• W2019977717 cites W2070256833 @default.
• W2019977717 cites W2071983551 @default.
• W2019977717 cites W2073554479 @default.
• W2019977717 cites W2078850755 @default.
• W2019977717 cites W2081386972 @default.
• W2019977717 cites W2083564688 @default.
• W2019977717 cites W2087563256 @default.
• W2019977717 cites W2087770419 @default.
• W2019977717 cites W2089311675 @default.
• W2019977717 cites W2090894469 @default.
• W2019977717 cites W2091230138 @default.
• W2019977717 cites W2101628242 @default.
• W2019977717 cites W2102734513 @default.
• W2019977717 cites W2106755981 @default.
• W2019977717 cites W2106862840 @default.
• W2019977717 cites W2116378709 @default.
• W2019977717 cites W2119352539 @default.
• W2019977717 cites W2121985684 @default.
• W2019977717 cites W2129465868 @default.
• W2019977717 cites W2130660740 @default.
• W2019977717 cites W2130733926 @default.
• W2019977717 cites W2140568669 @default.
• W2019977717 cites W2145709015 @default.
• W2019977717 cites W2147174358 @default.
• W2019977717 cites W2148905883 @default.
• W2019977717 cites W2149587761 @default.
• W2019977717 cites W2161951539 @default.
• W2019977717 cites W2161971927 @default.
• W2019977717 cites W2163190968 @default.
• W2019977717 cites W2165503499 @default.
• W2019977717 cites W2167417570 @default.
• W2019977717 cites W2313245085 @default.
• W2019977717 cites W2320138524 @default.
• W2019977717 cites W2326211238 @default.
• W2019977717 cites W2410249905 @default.
• W2019977717 cites W2983112567 @default.
• W2019977717 cites W377849966 @default.

• next