FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019977765> ?p ?o ?g. }

• W2019977765 endingPage "1006" @default.
• W2019977765 startingPage "995" @default.
• W2019977765 abstract "Abstract Purpose: Despite the frequent overexpression of epidermal growth factor receptor (EGFR) in squamous cell carcinoma (SCC), the efficacy of cetuximab alone is limited. Given the marked activity of namitecan, a hydrophilic camptothecin, against SCC models, the present study was performed to explore the efficacy of the cetuximab–namitecan combination in a panel of SCC models. Experimental Design: We examined the antiproliferative and antitumor activities of the cetuximab–namitecan combination in four SCC models characterized by a different EGFR gene copy number/EGFR protein level. We also assessed the effects of the combination on EGFR expression at both mRNA and protein levels and investigated the molecular basis of the interaction between the two agents. Results: Cetuximab and namitecan exhibited synergistic effects, resulting in potentiation of cell growth inhibition and, most importantly, enhanced therapeutic efficacy, with high cure rates in three SCC models characterized by high EGFR gene copy number, without increasing toxicity. The synergistic antitumor effect was also observed with the cetuximab–irinotecan combination. At the molecular level, the two agents produced a cooperative effect resulting in complete downregulation of EGFR. Interestingly, when singly administered, the camptothecin was able to strongly decrease EGFR expression mainly by transcriptional inhibition. Conclusions: Our results (i) demonstrate a marked efficacy of the cetuximab–namitecan combination, which reflects a complete abrogation of EGFR expression as a critical determinant of the therapeutic improvement, in SCC preclinical models, and (ii) suggest EGFR gene copy number as a possible marker to be used for patient selection in the clinical setting. Clin Cancer Res; 20(4); 995–1006. ©2013 AACR." @default.
• W2019977765 created "2016-06-24" @default.
• W2019977765 creator A5030514699 @default.
• W2019977765 creator A5033312783 @default.
• W2019977765 creator A5035095325 @default.
• W2019977765 creator A5045670524 @default.
• W2019977765 creator A5071309513 @default.
• W2019977765 creator A5075803217 @default.
• W2019977765 creator A5075852039 @default.
• W2019977765 creator A5091227333 @default.
• W2019977765 date "2014-02-15" @default.
• W2019977765 modified "2023-10-14" @default.
• W2019977765 title "Synergistic Antitumor Activity of Cetuximab and Namitecan in Human Squamous Cell Carcinoma Models Relies on Cooperative Inhibition of EGFR Expression and Depends on High EGFR Gene Copy Number" @default.
• W2019977765 cites W1557061959 @default.
• W2019977765 cites W1585913386 @default.
• W2019977765 cites W1964321121 @default.
• W2019977765 cites W1965757481 @default.
• W2019977765 cites W1967391569 @default.
• W2019977765 cites W1968961303 @default.
• W2019977765 cites W1983523103 @default.
• W2019977765 cites W1988442083 @default.
• W2019977765 cites W1988770284 @default.
• W2019977765 cites W2007115885 @default.
• W2019977765 cites W2007649418 @default.
• W2019977765 cites W2012753735 @default.
• W2019977765 cites W2014956732 @default.
• W2019977765 cites W2015495715 @default.
• W2019977765 cites W2026657556 @default.
• W2019977765 cites W2033725243 @default.
• W2019977765 cites W2037395954 @default.
• W2019977765 cites W2039950956 @default.
• W2019977765 cites W2046890706 @default.
• W2019977765 cites W2051120695 @default.
• W2019977765 cites W2063096553 @default.
• W2019977765 cites W2068125497 @default.
• W2019977765 cites W2076395634 @default.
• W2019977765 cites W2077576108 @default.
• W2019977765 cites W2077661824 @default.
• W2019977765 cites W2077945404 @default.
• W2019977765 cites W2079879369 @default.
• W2019977765 cites W2083215308 @default.
• W2019977765 cites W2092556174 @default.
• W2019977765 cites W2096702281 @default.
• W2019977765 cites W2097731357 @default.
• W2019977765 cites W2111726804 @default.
• W2019977765 cites W2112845420 @default.
• W2019977765 cites W2128668886 @default.
• W2019977765 cites W2136871952 @default.
• W2019977765 cites W2139819066 @default.
• W2019977765 cites W2142279958 @default.
• W2019977765 cites W2145460819 @default.
• W2019977765 cites W2149412903 @default.
• W2019977765 cites W2151730005 @default.
• W2019977765 cites W2152332206 @default.
• W2019977765 cites W2160126442 @default.
• W2019977765 cites W2160988875 @default.
• W2019977765 cites W2166630278 @default.
• W2019977765 cites W2167300285 @default.
• W2019977765 cites W2171578197 @default.
• W2019977765 doi "https://doi.org/10.1158/1078-0432.ccr-13-1684" @default.
• W2019977765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24327272" @default.
• W2019977765 hasPublicationYear "2014" @default.
• W2019977765 type Work @default.
• W2019977765 sameAs 2019977765 @default.
• W2019977765 citedByCount "7" @default.
• W2019977765 countsByYear W20199777652015 @default.
• W2019977765 countsByYear W20199777652016 @default.
• W2019977765 countsByYear W20199777652017 @default.
• W2019977765 countsByYear W20199777652019 @default.
• W2019977765 countsByYear W20199777652023 @default.
• W2019977765 crossrefType "journal-article" @default.
• W2019977765 hasAuthorship W2019977765A5030514699 @default.
• W2019977765 hasAuthorship W2019977765A5033312783 @default.
• W2019977765 hasAuthorship W2019977765A5035095325 @default.
• W2019977765 hasAuthorship W2019977765A5045670524 @default.
• W2019977765 hasAuthorship W2019977765A5071309513 @default.
• W2019977765 hasAuthorship W2019977765A5075803217 @default.
• W2019977765 hasAuthorship W2019977765A5075852039 @default.
• W2019977765 hasAuthorship W2019977765A5091227333 @default.
• W2019977765 hasBestOaLocation W20199777651 @default.
• W2019977765 hasConcept C104317684 @default.
• W2019977765 hasConcept C121608353 @default.
• W2019977765 hasConcept C126322002 @default.
• W2019977765 hasConcept C127561419 @default.
• W2019977765 hasConcept C2777506169 @default.
• W2019977765 hasConcept C2779438470 @default.
• W2019977765 hasConcept C2779682216 @default.
• W2019977765 hasConcept C2779707156 @default.
• W2019977765 hasConcept C2779998722 @default.
• W2019977765 hasConcept C502942594 @default.
• W2019977765 hasConcept C526805850 @default.
• W2019977765 hasConcept C54355233 @default.
• W2019977765 hasConcept C55493867 @default.
• W2019977765 hasConcept C62112901 @default.
• W2019977765 hasConcept C71924100 @default.
• W2019977765 hasConcept C86803240 @default.
• W2019977765 hasConcept C98274493 @default.
• W2019977765 hasConceptScore W2019977765C104317684 @default.

• next